Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-018-22379-6
Title: Cytokine and Chemokine Profiling in Patients with Hand, Foot and Mouth Disease in Singapore and Malaysia
Authors: Teo, Fiona Mei Shan
Nyo, Min 
Wong, Anng Anng
Tan, Natalie Woon Hui 
Koh, Mia Tuang
Chan, Yoke Fun
Chong, Chia Yin 
Chu, Justin Jang Hann 
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
ENTEROVIRUS 71 INFECTION
NERVE GROWTH-FACTOR
COXSACKIEVIRUS A6
INFLAMMATORY CYTOKINE
AIRWAY INFLAMMATION
INFLUENZA-VIRUS
RECEPTOR
EXPRESSION
EOTAXIN
CELLS
Issue Date: 6-Mar-2018
Publisher: NATURE PUBLISHING GROUP
Citation: Teo, Fiona Mei Shan, Nyo, Min, Wong, Anng Anng, Tan, Natalie Woon Hui, Koh, Mia Tuang, Chan, Yoke Fun, Chong, Chia Yin, Chu, Justin Jang Hann (2018-03-06). Cytokine and Chemokine Profiling in Patients with Hand, Foot and Mouth Disease in Singapore and Malaysia. SCIENTIFIC REPORTS 8 (1). ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-018-22379-6
Abstract: © 2018 The Author(s). Hand, foot and mouth disease (HFMD) is a prevalent contagious childhood disease typically associated with fever, oral lesions and limb exanthema. While HFMD is caused by a plethora of serotypes of viruses under the genus Enterovirus within the Picornaviridae family, Coxsackievirus A16 (CV-A16) and Enterovirus 71 (EV-A71) are considered the main etiological agents. In recent years however, other viruses have also been isolated in considerable numbers from infected individuals in many regions, joining the legion commonly associated with HFMD. The present study investigated the cytokine and chemokine profiles of HFMD patients from Singapore and Malaysia for the first time. Comparative cohort studies of EV-A71-associated HFMD cases revealed that the Malaysia cohort had a distinct profile from the Singapore cohort, and this could be partly attributed by different EV-A71 genotypes. As the isolation of CV-A6, instead of CV-A16, had become prevalent in the Singapore cohort, it was also of particular interest to study the differential cytokine and chemokine profiles. Our data revealed that overlapping as well as unique profiles exist between the two major causative clinical isolates in the Singapore cohort. Having a better understanding of the respective immunological profiles could be useful for more accurate HFMD diagnosis, which is imperative for disease transmission control until multi-valent vaccines and/or broad-spectrum anti-viral drugs become available.
Source Title: SCIENTIFIC REPORTS
URI: https://scholarbank.nus.edu.sg/handle/10635/170671
ISSN: 20452322
DOI: 10.1038/s41598-018-22379-6
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