Please use this identifier to cite or link to this item:
Title: Time-resolved small-angle neutron scattering as a probe for the dynamics of lipid exchange between human lipoproteins and naturally derived membranes
Authors: Maric, S
Lind, TK
Raida, MR 
Bengtsson, E
Fredrikson, GN
Rogers, S
Moulin, M
Haertlein, M
Forsyth, VT
Wenk, MR 
Pomorski, TG
Arnebrant, T
Lund, R
Cárdenas, M
Issue Date: 2019
Publisher: Springer Science and Business Media LLC
Citation: Maric, S, Lind, TK, Raida, MR, Bengtsson, E, Fredrikson, GN, Rogers, S, Moulin, M, Haertlein, M, Forsyth, VT, Wenk, MR, Pomorski, TG, Arnebrant, T, Lund, R, Cárdenas, M (2019). Time-resolved small-angle neutron scattering as a probe for the dynamics of lipid exchange between human lipoproteins and naturally derived membranes. Scientific Reports 9 (1) : 7591-. ScholarBank@NUS Repository.
Abstract: © 2019, The Author(s). Atherosclerosis is the main killer in the western world. Today’s clinical markers include the total level of cholesterol and high-/low-density lipoproteins, which often fails to accurately predict the disease. The relationship between the lipid exchange capacity and lipoprotein structure should explain the extent by which they release or accept lipid cargo and should relate to the risk for developing atherosclerosis. Here, small-angle neutron scattering and tailored deuteration have been used to follow the molecular lipid exchange between human lipoprotein particles and cellular membrane mimics made of natural, “neutron invisible” phosphatidylcholines. We show that lipid exchange occurs via two different processes that include lipid transfer via collision and upon direct particle tethering to the membrane, and that high-density lipoprotein excels at exchanging the human-like unsaturated phosphatidylcholine. By mapping the specific lipid content and level of glycation/oxidation, the mode of action of specific lipoproteins can now be deciphered. This information can prove important for the development of improved diagnostic tools and in the treatment of atherosclerosis.
Source Title: Scientific Reports
ISSN: 20452322
DOI: 10.1038/s41598-019-43713-6
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
56. Time-resolved_small-angle_neut.pdfPublished version2.69 MBAdobe PDF




checked on Jan 16, 2021

Page view(s)

checked on Jan 15, 2021


checked on Jan 15, 2021

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.