Please use this identifier to cite or link to this item: https://doi.org/10.1021/acsami.9b00294
Title: Surface-Layer Protein-Enhanced Immunotherapy Based on Cell Membrane-Coated Nanoparticles for the Effective Inhibition of Tumor Growth and Metastasis
Authors: Wu, Min 
Liu, Xingang 
Bai, Hongzhen
Lai, Lihua
Chen, Qi 
Huang, Guojun
Liu, Bin 
Tang, Guping 
Keywords: Science & Technology
Technology
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Science & Technology - Other Topics
Materials Science
Cancer cell membrane
Biomimetic nanoparticles
Cancer immunotherapy
Surface-layer protein
Myeloid-derived suppressor cells
CANCER-IMMUNOTHERAPY
SUPPRESSOR-CELLS
CHEMOTHERAPY
COMBINATION
MOLECULES
MICELLES
Issue Date: 13-Mar-2019
Publisher: AMERICAN CHEMICAL SOCIETY
Citation: Wu, Min, Liu, Xingang, Bai, Hongzhen, Lai, Lihua, Chen, Qi, Huang, Guojun, Liu, Bin, Tang, Guping (2019-03-13). Surface-Layer Protein-Enhanced Immunotherapy Based on Cell Membrane-Coated Nanoparticles for the Effective Inhibition of Tumor Growth and Metastasis. ACS APPLIED MATERIALS & INTERFACES 11 (10) : 9850-9859. ScholarBank@NUS Repository. https://doi.org/10.1021/acsami.9b00294
Abstract: © 2019 American Chemical Society. Chemo-immunotherapy is an important tool to overcome tumor immune suppression in cancer immunotherapy. Herein, we report a surface-layer (S-layer) protein-enhanced immunotherapy strategy based on cell membrane-coated S-CM-HPAD nanoparticles for the effective malignant tumor therapy and metastasis inhibition. The S-CM-HPAD NPs could effectively deliver the tumor antigen, DOX, and immunoadjuvant to the homotypic tumor by the homotypic targeting ability of the coated cell membrane. In addition to its ability to induce tumor cell death, the loaded DOX could enhance the immunotherapy response by inhibition of myeloid-derived suppressor cells (MDSCs). Because of the intrinsic adjuvant property and capability to surface display epitopes and proteins, the S-layers localized on the surface of S-CM-HPAD NPs potentiated the immune response to the antigen. The results confirmed that the protective immunity against tumor occurrence was promoted effectively by prompting proliferation of lymphocytes and secretion of cytokine caused by the tumor-associated antigen and adjuvant. The excellent combinational therapeutic effects on the inhibition of tumor growth and metastasis in the melanoma tumor models demonstrated that the S-layer-enhanced immunotherapeutic method is a promising strategy for tumor immunotherapy of malignant tumor growth and metastasis.
Source Title: ACS APPLIED MATERIALS & INTERFACES
URI: https://scholarbank.nus.edu.sg/handle/10635/170007
ISSN: 19448244
19448252
DOI: 10.1021/acsami.9b00294
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
manuscript-AMI.pdfAccepted version1.09 MBAdobe PDF

OPEN

Post-printView/Download

SCOPUSTM   
Citations

14
checked on Oct 19, 2020

Page view(s)

43
checked on Oct 16, 2020

Download(s)

1
checked on Oct 16, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.