Please use this identifier to cite or link to this item: https://doi.org/10.1021/acsnano.7b00312
Title: One-Step Formulation of Targeted Aggregation-Induced Emission Dots for Image-Guided Photodynamic Therapy of Cholangiocarcinoma
Authors: Li, Min
Gao, Yang
YUAN YOUYONG 
Wu, Yuzhe
Song, Zifang
Tang, Ben Zhong
LIU BIN 
Zheng, Qi Chang
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Chemistry
Science & Technology - Other Topics
Materials Science
cholangiocarcinoma
aggregation-induced emission
targeted fluorescence imaging
photodynamic therapy
targeted therapy
CANCER-CELLS
NONRESECTABLE CHOLANGIOCARCINOMA
AIE CHARACTERISTICS
PHOTOSENSITIZER
BIOPROBES
NANOPARTICLES
ACTIVATION
TOXICITY
ABLATION
Issue Date: 1-Apr-2017
Publisher: American Chemical Society
Citation: Li, Min, Gao, Yang, YUAN YOUYONG, Wu, Yuzhe, Song, Zifang, Tang, Ben Zhong, LIU BIN, Zheng, Qi Chang (2017-04-01). One-Step Formulation of Targeted Aggregation-Induced Emission Dots for Image-Guided Photodynamic Therapy of Cholangiocarcinoma. ACS Nano 11 (4) : 3922-3932. ScholarBank@NUS Repository. https://doi.org/10.1021/acsnano.7b00312
Abstract: Photodynamic therapy (PDT) is a palliative technique that can improve median survival with minimal invasion for cholangiocarcinoma (CC) patients. An ideal photosensitizer (PS) is critical to guarantee the efficacy of PDT. However, conventional PSs have some obvious drawbacks, such as lack of specificity and easy aggregation in aqueous media that limit their further application in the clinic. We herein fully take advantage of a red emissive aggregation-induced emission (AIE) PS to fabricate integrin ανβ3 targeted organic AIE dots for image-guided PDT via a simple and straightforward one-step strategy. The obtained AIE dots exhibit high specificity to CC as well as excellent antitumor effect both in vitro and in vivo. Different from conventional PSs and previously reported PS-loaded nanostructures, the AIE dots do not suffer from aggregation-caused fluorescence quenching and reduction in reactive oxygen species production when the AIE PS molecules are in an aggregated state. The significant antitumor effect, as well as good biocompatibility and negligible toxicity, makes the AIE dots promising for future translational research in CC diagnosis and therapy.
Source Title: ACS Nano
URI: https://scholarbank.nus.edu.sg/handle/10635/169784
ISSN: 1936-0851
1936-086X
DOI: 10.1021/acsnano.7b00312
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