Please use this identifier to cite or link to this item: https://doi.org/10.1039/c6sc03859j
Title: AIEgen-based theranostic system: targeted imaging of cancer cells and adjuvant amplification of antitumor efficacy of paclitaxel
Authors: Chen, Chao
Song, Zhegang
Zheng, Xiaoyan
He, Zikai
LIU BIN 
Huang, Xuhui
Kong, Deling
Ding, Dan
Tang, Ben Zhong
Keywords: Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
AGGREGATION-INDUCED EMISSION
SEMICONDUCTOR QUANTUM DOTS
PHOTODYNAMIC THERAPY
IN-VIVO
EPHA2 RECEPTOR
NANOPARTICLES
PHOTOSENSITIZER
ACTIVATION
DELIVERY
LIGHT
Issue Date: 1-Mar-2017
Publisher: Royal Society of Chemistry (RSC)
Citation: Chen, Chao, Song, Zhegang, Zheng, Xiaoyan, He, Zikai, LIU BIN, Huang, Xuhui, Kong, Deling, Ding, Dan, Tang, Ben Zhong (2017-03-01). AIEgen-based theranostic system: targeted imaging of cancer cells and adjuvant amplification of antitumor efficacy of paclitaxel. Chemical Science 8 (3) : 2191-2198. ScholarBank@NUS Repository. https://doi.org/10.1039/c6sc03859j
Abstract: Photosensitizers are generally treated as key components for photodynamic therapy. In contrast, we herein report an aggregation-induced emission luminogen (AIEgen)-based photosensitizer (TPE-Py-FFGYSA) that can serve as a non-toxic adjuvant to amplify the antitumor efficacy of paclitaxel, a well-known anticancer drug, with a synergistic effect of “0 + 1 > 1”. Besides the adjuvant function, TPE-Py-FFGYSA can selectively light up EphA2 protein clusters overexpressed in cancer cells in a fluorescence turn-on mode, by taking advantage of the specific YSA peptide (YSAYPDSVPMMS)-EphA2 protein interaction. The simple incorporation of FFG as a self-assembly-aided unit between AIEgen (TPE-Py) and YSA significantly enhances the fluorescent signal output of TPE-Py when imaging EphA2 clusters in live cancer cells. Cytotoxicity and western blot studies reveal that the reactive oxygen species (ROS) generated by TPE-Py-FFGYSA upon exposure to light do not kill cancer cells, but instead provide an intracellular oxidative environment to help paclitaxel have much better efficacy. This study thus not only extends the application scope of photosensitizers, but also offers a unique theranostic system with the combination of diagnostic imaging and adjuvant antitumor therapy.
Source Title: Chemical Science
URI: https://scholarbank.nus.edu.sg/handle/10635/169779
ISSN: 2041-6520
2041-6539
DOI: 10.1039/c6sc03859j
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