Please use this identifier to cite or link to this item: https://doi.org/10.1002/adma.201706831
Title: Metal-Organic-Framework-Assisted In Vivo Bacterial Metabolic Labeling and Precise Antibacterial Therapy
Authors: MAO DUO 
Hu, Fang
KENRY 
Ji, Shenglu
Wu, Wenbo
Ding, Dan
Kong, Deling
LIU BIN 
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Physics, Condensed Matter
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
aggregation-induced emission
antibacterial therapy
bacteria imaging
metabolic labeling
metal-organic frameworks
HYDROGEN-PEROXIDE
DRUG-DELIVERY
CANCER
PEPTIDOGLYCAN
NANOPARTICLES
INFECTION
REPAIR
LIGHT
Issue Date: 3-May-2018
Publisher: Wiley-VCH Verlag
Citation: MAO DUO, Hu, Fang, KENRY, Ji, Shenglu, Wu, Wenbo, Ding, Dan, Kong, Deling, LIU BIN (2018-05-03). Metal-Organic-Framework-Assisted In Vivo Bacterial Metabolic Labeling and Precise Antibacterial Therapy. ADVANCED MATERIALS 30 (18). ScholarBank@NUS Repository. https://doi.org/10.1002/adma.201706831
Abstract: Bacterial infection is one of the most serious physiological conditions threatening human health. There is an increasing demand for more effective bacterial diagnosis and treatment through noninvasive theranostic approaches. Herein, a new strategy is reported to achieve in vivo metabolic labeling of bacteria through the use of MIL-100 (Fe) nanoparticles (NPs) as the nanocarrier for precise delivery of 3-azido-d-alanine (d-AzAla). After intravenous injection, MIL-100 (Fe) NPs can accumulate preferentially and degrade rapidly within the high H2O2 inflammatory environment, releasing d-AzAla in the process. d-AzAla is selectively integrated into the cell walls of bacteria, which is confirmed by fluorescence signals from clickable DBCO-Cy5. Ultrasmall photosensitizer NPs with aggregation-induced emission characteristics are subsequently designed to react with the modified bacteria through in vivo click chemistry. Through photodynamic therapy, the amount of bacteria on the infected tissue can be significantly reduced. Overall, this study demonstrates the advantages of metal–organic-framework-assisted bacteria metabolic labeling strategy for precise bacterial detection and therapy guided by fluorescence imaging.
Source Title: ADVANCED MATERIALS
URI: https://scholarbank.nus.edu.sg/handle/10635/169660
ISSN: 0935-9648
1521-4095
DOI: 10.1002/adma.201706831
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