Please use this identifier to cite or link to this item: https://doi.org/10.1002/anie.201601744
Title: Bioorthogonal Turn-On Probe Based on Aggregation-Induced Emission Characteristics for Cancer Cell Imaging and Ablation
Authors: YUAN YOUYONG 
XU SHIDANG 
Cheng, Xiamin
CAI XIAOLEI 
LIU BIN 
Keywords: Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
aggregation-induced emission (AIE)
bioorthogonal probe
click chemistry
imaging
phototherapy
LIGHT-UP PROBE
PHOTODYNAMIC THERAPY
FLUOROGENIC PROBES
CHEMISTRY
FLUORESCENCE
DELIVERY
BIOPROBE
GLYCANS
RED
Issue Date: 23-May-2016
Publisher: WILEY
Citation: YUAN YOUYONG, XU SHIDANG, Cheng, Xiamin, CAI XIAOLEI, LIU BIN (2016-05-23). Bioorthogonal Turn-On Probe Based on Aggregation-Induced Emission Characteristics for Cancer Cell Imaging and Ablation. Angewandte Chemie - International Edition 55 (22) : 6457-6461. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201601744
Abstract: Bioorthogonal turn-on probes have been widely utilized in visualizing various biological processes. Most of the currently available bioorthogonal turn-on probes are blue or green emissive fluorophores with azide or tetrazine as functional groups. Herein, we present an alternative strategy of designing bioorthogonal turn-on probes based on red-emissive fluorogens with aggregation-induced emission characteristics (AIEgens). The probe is water soluble and non-fluorescent due to the dissipation of energy through free molecular motion of the AIEgen, but the fluorescence is immediately turned on upon click reaction with azide-functionalized glycans on cancer cell surface. The fluorescence turn-on is ascribed to the restriction of molecular motion of AIEgen, which populates the radiative decay channel. Moreover, the AIEgen can generate reactive oxygen species (ROS) upon visible light (λ=400-700 nm) irradiation, demonstrating its dual role as an imaging and phototherapeutic agent. Fast and specific: A bioorthogonal turn-on probe based on a red-emissive fluorogen with aggregation-induced emission characteristics (AIEgen) was developed for cancer cell imaging and photodynamic ablation. The fluorescence is immediately turned on upon click reaction with azide-functionalized glycans on a cancer cell surface.
Source Title: Angewandte Chemie - International Edition
URI: https://scholarbank.nus.edu.sg/handle/10635/169650
ISSN: 1433-7851
1521-3773
DOI: 10.1002/anie.201601744
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