Please use this identifier to cite or link to this item: https://doi.org/10.1039/c6sc05421h
Title: Visualization of drug delivery processes using AIEgens
Authors: YUAN YOUYONG 
LIU BIN 
Keywords: Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
AGGREGATION-INDUCED-EMISSION
LIGHT-UP PROBE
THERANOSTIC PLATINUM(IV) PRODRUG
PHOTODYNAMIC THERAPY
CANCER-CELLS
IN-SITU
AIE CHARACTERISTICS
SINGLET OXYGEN
FAR-RED
TURN-ON
Issue Date: 1-Apr-2017
Publisher: Royal Society of Chemistry (RSC)
Citation: YUAN YOUYONG, LIU BIN (2017-04-01). Visualization of drug delivery processes using AIEgens. Chemical Science 8 (4) : 2537-2546. ScholarBank@NUS Repository. https://doi.org/10.1039/c6sc05421h
Abstract: Drug delivery systems (DDSs) have been extensively studied as carriers to deliver small molecule chemo-drugs to tumors for cancer therapy. The therapeutic efficiency of chemo-drugs is crucially dependent on the effective drug concentrations in tumors and cancer cells. Novel DDSs that can simultaneously unveil drug distribution, drug release/activation behaviors and offer early evaluation of their therapeutic responses are highly desirable. Traditional fluorescent dye-labeled DDSs may suffer from notorious aggregation-caused quenching (ACQ) with limited sensitivity for bioimaging; in addition, the intrinsic fluorescence of these dyes requires careful selection of energy acceptor or quencher moieties for a light-up probe design, which complicates the development of self-reporting DDSs, especially the ones for reporting multiple processes. The recently emerged fluorogens with aggregation-induced emission characteristics (AIEgens) offer a straightforward solution to tackle this challenge. Thanks to the unique properties of AIEgens, new theranostic DDSs have been developed for simultaneous drug delivery and bioimaging with high signal to background ratio and multiple signal reporting capabilities. In this mini-review, we summarize the recent development of theranostic DDSs based on AIEgens for monitoring the drug distribution, drug activation and prediction of the therapeutic responses. Through illustration of their design principles and application examples, we hope to stimulate the interest in the design of more advanced theranostic DDSs for biomedical research.
Source Title: Chemical Science
URI: https://scholarbank.nus.edu.sg/handle/10635/169645
ISSN: 2041-6520
2041-6539
DOI: 10.1039/c6sc05421h
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