Please use this identifier to cite or link to this item: https://doi.org/10.1021/acs.chemmater.9b04520
Title: Bio-Orthogonal AlEgen for Specific Discrimination and Elimination of Bacterial Pathogens via Metabolic Engineering
Authors: Wu, Min 
Qi, Guobin
Liu, Xingang 
Duan, Yukun 
Liu, Jingjing 
Liu, Bin 
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Physical
Materials Science, Multidisciplinary
Chemistry
Materials Science
AGGREGATION-INDUCED EMISSION
PHOTODYNAMIC THERAPY
AMINO-ACIDS
MALDI-TOF
IDENTIFICATION
PEPTIDOGLYCAN
CANDIDA
MANNOPROTEIN
ANTIBIOTICS
PCR
Issue Date: 28-Jan-2020
Publisher: AMERICAN CHEMICAL SOCIETY
Citation: Wu, Min, Qi, Guobin, Liu, Xingang, Duan, Yukun, Liu, Jingjing, Liu, Bin (2020-01-28). Bio-Orthogonal AlEgen for Specific Discrimination and Elimination of Bacterial Pathogens via Metabolic Engineering. CHEMISTRY OF MATERIALS 32 (2) : 858-865. ScholarBank@NUS Repository. https://doi.org/10.1021/acs.chemmater.9b04520
Abstract: Copyright © 2019 American Chemical Society. Multiple bacterial infections caused by interpatient spread lead to complications in diagnosis and clinical management, seriously threatening human health. In this contribution, we design a bio-orthogonal fluorescence turn-on probe TPEPA for the discrimination and precise ablation of bacterial pathogens. The probe has good water solubility and negligible fluorescence in aqueous media. On clicking with the azide groups decorated on bacteria by metabolic engineering, it shows fluorescence turn-on with far-red/near-infrared emission. Taking advantage of the difference in bacterial structures, TPEPA can discriminate pathogens via selective imaging of metabolically decorated Gram-negative bacteria with Kdo-N3 and Gram-positive bacteria with d-Ala-N3, respectively, even in a mixture. Furthermore, TPEPA can effectively generate reactive oxygen species, which allows imaging, discrimination, and precise ablation functions to be integrated into one system to realize a selective antimicrobial effect.
Source Title: CHEMISTRY OF MATERIALS
URI: https://scholarbank.nus.edu.sg/handle/10635/169600
ISSN: 08974756
15205002
DOI: 10.1021/acs.chemmater.9b04520
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