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Title: Membrane-Anchoring Photosensitizer with Aggregation-Induced Emission Characteristics for Combating Multidrug-Resistant Bacteria
Authors: Chen, H 
Li, S
Wu, M 
Huang, Z
Lee, CS
Liu, B 
Keywords: aggregation-induced emission
antibacterial activity
fluorescence imaging
membrane anchor
photodynamic therapy
Issue Date: 7-Jan-2020
Publisher: Wiley
Citation: Chen, H, Li, S, Wu, M, Kenry, Huang, Z, Lee, CS, Liu, B (2020-01-07). Membrane-Anchoring Photosensitizer with Aggregation-Induced Emission Characteristics for Combating Multidrug-Resistant Bacteria. Angewandte Chemie - International Edition 59 (2) : 632-636. ScholarBank@NUS Repository.
Abstract: © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Traditional photosensitizers (PSs) show reduced singlet oxygen (1O2) production and quenched fluorescence upon aggregation in aqueous media, which greatly affect their efficiency in photodynamic therapy (PDT). Meanwhile, non-targeting PSs generally yield low efficiency in antibacterial performance due to their short lifetimes and small effective working radii. Herein, a water-dispersible membrane anchor (TBD-anchor) PS with aggregation-induced emission is designed and synthesized to generate 1O2 on the bacterial membrane. TBD-anchor showed efficient antibacterial performance towards both Gram-negative (Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus). Over 99.8 % killing efficiency was obtained for methicillin-resistant S. aureus (MRSA) when they were exposed to 0.8 μm of TBD-anchor at a low white light dose (25 mW cm−2) for 10 minutes. TBD-anchor thus shows great promise as an effective antimicrobial agent to combat the menace of multidrug-resistant bacteria.
Source Title: Angewandte Chemie - International Edition
ISSN: 14337851
DOI: 10.1002/anie.201907343
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