Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.coviro.2019.02.002
Title: Structural perspectives of antibody-dependent enhancement of infection of dengue virus
Authors: Seamus R Morrone 
Shee-Mei Lok 
Issue Date: 3-Jun-2019
Citation: Seamus R Morrone, Shee-Mei Lok (2019-06-03). Structural perspectives of antibody-dependent enhancement of infection of dengue virus. ScholarBank@NUS Repository. https://doi.org/10.1016/j.coviro.2019.02.002
Abstract: Dengue virus (DENV) consists of four serotypes. Sequential serotype infections can cause increased disease severity, likely due to antibody-dependent enhancement (ADE) of infection. Here, we review two recent papers showing major advancements in the understanding of the ADE mechanism for both mature and immature DENV. The surface of both mature and immature DENV contains E and another protein - M in mature and prM in immature virus. On mature DENV, the orientation of anti-E antibody with respect to the virus surface determines the antibody enhancement properties. On the immature virus, binding of anti-prM antibody aids the dissociation of pr from the fusion loop of E protein allowing virus-endosomal membrane interaction, thus overcoming the hurdle in the early step of fusion.
URI: https://scholarbank.nus.edu.sg/handle/10635/169164
ISSN: 18796257
DOI: 10.1016/j.coviro.2019.02.002
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