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Title: CMV latent infection improves CD8+ T response to SEB due to expansion of polyfunctional CD57+ cells in young individuals
Authors: Pera A.
Campos C.
Corona A.
Sanchez-Correa B.
Tarazona R.
Larbi A. 
Solana R.
Keywords: CD57 antigen
gamma interferon
lysosome associated membrane protein 1
Staphylococcus enterotoxin B
tumor necrosis factor alpha
CD3 antigen
enterotoxin B, staphylococcal
gamma interferon
tumor necrosis factor alpha
antigen expression
CD57+ T lymphocyte
CD8+ T lymphocyte
cell expansion
clinical article
controlled study
cytokine production
cytomegalovirus infection
human cell
immune response
lymphocyte function
lymphocyte proliferation
middle aged
T lymphocyte
CD8+ T lymphocyte
cytomegalovirus infection
flow cytometry
gene expression regulation
mononuclear cell
young adult
Age Factors
Antigens, CD3
Antigens, CD57
CD8-Positive T-Lymphocytes
Cytomegalovirus Infections
Flow Cytometry
Gene Expression Regulation
Leukocytes, Mononuclear
Lysosomal-Associated Membrane Protein 1
Middle Aged
Tumor Necrosis Factor-alpha
Young Adult
Issue Date: 2014
Publisher: Public Library of Science
Citation: Pera A., Campos C., Corona A., Sanchez-Correa B., Tarazona R., Larbi A., Solana R. (2014). CMV latent infection improves CD8+ T response to SEB due to expansion of polyfunctional CD57+ cells in young individuals. PLoS ONE 9 (2) : e88538. ScholarBank@NUS Repository.
Abstract: Cytomegalovirus (CMV) latent infection has a deleterious effect on the efficacy of influenza vaccination in the elderly, suggesting that CMV restricts immunological diversity impairing the immune system functionality in old age. Polyfunctional T cells produce multiple cytokines and higher amounts than mono-functional T cells. High number of polyfunctional T cells correlates with better prognosis during infection. Thus, the efficiency of T cell response associates with quality (polyfunctionality) rather than with quantity (percentage of T cells). We analyze the effect of CMV infection on CD8+ T cells polyfunctionality -degranulation (CD107a), IFN-gamma and TNF-alpha production-, from young CMV-seropositive and CMV-seronegative individuals and in middle age CMV-seropositive donors, in response to Staphylococcal Enterotoxin B (SEB). Our results show a higher percentage of polyfunctional CD8+ T cells in young CMV-seropositive individuals compared to CMV-seronegative. Also, we find an expansion of CD8+CD57+ T cells in CMV-seropositive individuals, which are more polyfunctional than CD8+ CD57- cells. In middle age individuals there is a higher frequency of SEB-responding CD8+ T cells, mainly TNF-alpha or TNF-alpha/IFN-gamma producers, whereas the percentage of polyfunctional cells (IFN-gamma/TNF-alpha/CD107a) is similar to the percentages found in young CMV-seropositive. Therefore, whereas it has been shown that CMV latent infection can be detrimental for immune response in old individuals, our results indicate that CMV-seropositivity is associated to higher levels of polyfunctional CD8+ T cells in young and middle age donors. This increase in polyfunctionality, which can provide an immunological advantage in the response to other pathogens, is due to a CD8+CD57+ T cell expansion in CMV-seropositive individuals and it is independent of age. Conversely, age could contribute to the inflammation found in old individuals by increasing the percentage of cells producing pro-inflammatory cytokines. These findings highlight the necessity of further studies on the benefits/detrimental effects of CMV infection in the response to vaccination and other infections. © 2014 Pera et al.
Source Title: PLoS ONE
ISSN: 19326203
DOI: 10.1371/journal.pone.0088538
Appears in Collections:Staff Publications

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