Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0156949
Title: Differential expression patterns of egf, egfr, and erbb4 in nasal polyp epithelium
Authors: Duan C.
Li C.W. 
Zhao L.
Subramaniam S.
Yu X.M.
Li Y.Y. 
De Chen H.
Li T.Y.
Shen L.
Shi L. 
De Wang Y. 
Keywords: alpha tubulin
epidermal growth factor
epidermal growth factor receptor
epidermal growth factor receptor 4
glucocorticoid
messenger RNA
protein p63
EGFR protein, human
epidermal growth factor
epidermal growth factor receptor
epidermal growth factor receptor 4
ERBB4 protein, human
adult
Article
basal cell
cell hyperplasia
cell infiltration
cell surface
cellular distribution
Chinese
comparative study
controlled study
disease association
female
gene expression profiling
gene expression regulation
goblet cell
histopathology
human
human cell
human tissue
inflammatory cell
intracellular signaling
major clinical study
male
molecular dynamics
nose mucosa
nose polyp
polypectomy
protein expression
protein localization
transcription regulation
upregulation
case control study
gene expression profiling
genetics
metabolism
middle aged
nose mucosa
nose polyp
pathology
physiology
regeneration
young adult
Adult
Case-Control Studies
Epidermal Growth Factor
Female
Gene Expression Profiling
Humans
Male
Middle Aged
Nasal Mucosa
Nasal Polyps
Receptor, Epidermal Growth Factor
Receptor, ErbB-4
Regeneration
Young Adult
Issue Date: 2016
Publisher: Public Library of Science
Citation: Duan C., Li C.W., Zhao L., Subramaniam S., Yu X.M., Li Y.Y., De Chen H., Li T.Y., Shen L., Shi L., De Wang Y. (2016). Differential expression patterns of egf, egfr, and erbb4 in nasal polyp epithelium. PLoS ONE 11 (6) : e0156949. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0156949
Abstract: Epidermal growth factor receptors play an important role in airway epithelial cell growth and differentiation. The current study investigates the expression profiles of EGF, EGFR and ERBB4 in patients with nasal polyps (NP), and their response to glucocorticosteroid (GC) treatment. Fifty patients with NP (40 without GC treatment and 10 with oral GC) and 20 control subjects with septal deviation were recruited into the study. Protein levels of EGF, EGFR, and ERBB4 were evaluated by immune-staining. In healthy nasal epithelium, EGF and EGFR localized within p63 + basal cells, while ERBB4 localized within ciliated cells. GCnaïve NP epithelium showed weak expression of EGF in 90% of samples versus 5% of controls. EGFR was significantly increased in the epithelium with basal cell hyperplasia from GC-naïve NPs (78%, 31/40) compared to controls (23%, 4/17). EGFR was also found in some degranulating goblet cells. ERBB4 expression was significantly higher in hyperplastic epithelium from GC-naïve NPs (65%, 26/40) than in controls (6%, 1/17). GC treatment restored the EGF expression and normalized the EGFR and ERBB4 expression in NPs. Differential expression patterns of EGF, EGFR, and ERBB4 are essential in epithelial restitution and remodeling in nasal epithelium. © 2016 Duan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Source Title: PLoS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/165746
ISSN: 19326203
DOI: 10.1371/journal.pone.0156949
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