Please use this identifier to cite or link to this item: https://doi.org/10.14670/HH-22.729
Title: Identification of differentially expressed genes in fetal rat forebrain exposed to a teratogen by cDNA microarray analysis
Authors: Dheen, ST 
Hao, AJ
Fu, J 
Gopalakrishnakone, P 
Ling, E-A 
Keywords: Amoeboid microglia/brain macrophages
Fetal forebrain
Inflammation genes
Microarray
Teratogen
Issue Date: 1-Jul-2007
Publisher: F HERNANDEZ
Citation: Dheen, ST, Hao, AJ, Fu, J, Gopalakrishnakone, P, Ling, E-A (2007-07-01). Identification of differentially expressed genes in fetal rat forebrain exposed to a teratogen by cDNA microarray analysis. HISTOLOGY AND HISTOPATHOLOGY 22 (7) : 729-742. ScholarBank@NUS Repository. https://doi.org/10.14670/HH-22.729
Abstract: In an attempt to understand the molecular basis untyling the neural tube defects induced by the teratogen, cyclophosphamide (CP), cDNA microarray analysis was carried out in neural tubes of embryos derived from normal and CP-treated rats. Genes found to have altered expression levels in CP-treated group were clustered into groups on the basis of their biological functions. The expression profile of different genes involved in transcription of molecules related to cell adhesion, inflammation, metabolism and neurotrophic factors pathways as well as in still undefined processes was differentially affected by the teratogen treatment. The most remarkable change was the up-regulation of genes related to an inflammatory process dominated by the fetal brain macrophages viz. amoeboid microglia. Amoeboid microglia/brain macrophage expansion, based on gene expression and histological analysis, was found to be vigorous at the subventricular region. The present results suggest that a vigorous inflammatory response involving amoeboid microglia/brain macrophages primarily is an important component in CP-induced prenatal development disorder.
Source Title: HISTOLOGY AND HISTOPATHOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/163913
ISSN: 02133911
16995848
DOI: 10.14670/HH-22.729
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