Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.nlm.2019.107039
Title: Activation of microglia in acute hippocampal slices affects activity-dependent long-term potentiation and synaptic tagging and capture in area CA1
Authors: Raghuraman, Radha
Karthikeyan, Aparna 
Wei, Wong Lik 
Dheen, S Thameem 
Sajikumar, Sreedharan
Keywords: Science & Technology
Social Sciences
Life Sciences & Biomedicine
Behavioral Sciences
Neurosciences
Psychology
Psychology, Multidisciplinary
Neurosciences & Neurology
Microglia
Neuron-glial interaction
Long term potentiation
Synaptic tagging/capture
LIPOSOME-ENCAPSULATED CLODRONATE
TNF-ALPHA
TRANSGENIC MICE
MEMORY
BISPHOSPHONATES
MACROPHAGES
MECHANISMS
PLASTICITY
CELLS
INTERLEUKIN-1-BETA
Issue Date: 1-Sep-2019
Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation: Raghuraman, Radha, Karthikeyan, Aparna, Wei, Wong Lik, Dheen, S Thameem, Sajikumar, Sreedharan (2019-09-01). Activation of microglia in acute hippocampal slices affects activity-dependent long-term potentiation and synaptic tagging and capture in area CA1. NEUROBIOLOGY OF LEARNING AND MEMORY 163. ScholarBank@NUS Repository. https://doi.org/10.1016/j.nlm.2019.107039
Abstract: © 2019 Elsevier Inc. Activity dependent setting of synaptic tags is critical for the establishment and maintenance of long-term plasticity and its associative properties such as synaptic tagging and capture (STC), a widely studied cellular model of associative memory. Although the known mechanisms of STC such as setting of synaptic tags or distribution of plasticity related proteins (PRPs) are the processes mainly happening within the neuronal compartments, the role of non-neuronal components is still elusive. Here, we report that microglia has a specific role in setting the synaptic tags and thus promotes long-term plasticity and STC. Treatment of hippocampal slices with clodronate, a specific inhibitor of microglia, resulted in an activated morphology of microglia but not of the hippocampal pyramidal neurons, oligodendrocytes or astrocytes. Activation of microglia before or 60 min after the induction of long-term plasticity prevented its maintenance and thus the expression of STC. Interestingly, activation of microglia 2 h after the induction of long-term plasticity neither prevented its maintenance nor its associative interaction with activated nearby synaptic populations. Given the half-life of synaptic tags is until about 60–90 min, activation of microglia beyond this time point while the maintenance phase is still unperturbed, suggests a lack of microglial interference in the synthesis or trigger of plasticity related products. Thus, our study provides the first evidence that microglia play a critical role in the setting of synaptic tags during the early phase of activity dependent plasticity.
Source Title: NEUROBIOLOGY OF LEARNING AND MEMORY
URI: https://scholarbank.nus.edu.sg/handle/10635/163873
ISSN: 10747427
10959564
DOI: 10.1016/j.nlm.2019.107039
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