Please use this identifier to cite or link to this item: https://doi.org/10.1093/cvr/cvz227
Title: Circles in the heart and cardiovascular system.
Authors: LIM TINGSEN BENSON 
Lavenniah, Annadoray
ROGER FOO SIK YIN 
Keywords: Cardiovascular disease
Circular RNA
Gene therapy
MicroRNA
Non-coding RNAs
Issue Date: 25-Sep-2019
Publisher: Oxford University Press (OUP)
Citation: LIM TINGSEN BENSON, Lavenniah, Annadoray, ROGER FOO SIK YIN (2019-09-25). Circles in the heart and cardiovascular system.. Cardiovasc Res. ScholarBank@NUS Repository. https://doi.org/10.1093/cvr/cvz227
Abstract: The combination of next-generation sequencing, advanced bioinformatics analysis, and molecular research has now established circular RNAs (circRNAs) as a heterogeneous group of non-coding RNA that is widely and abundantly expressed. CircRNAs are single-stranded RNA, covalently backspliced to form closed circular loops. Different models of back-splicing have been proposed, and mechanisms for circRNA function include sequestering microRNAs, direct interaction with proteins, regulation of transcription, and translation. Exploring the role of circRNAs in different disease settings, and understanding how they contribute to disease progression promises to provide valuable insight into potential novel therapeutic approaches. Here, we review the growing number of published research on circRNAs in the heart and cardiovascular system and summarize the circRNAs that have been implicated in disease.
Source Title: Cardiovasc Res
URI: https://scholarbank.nus.edu.sg/handle/10635/162088
ISSN: 0008-6363
1755-3245
DOI: 10.1093/cvr/cvz227
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