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https://doi.org/10.1093/cvr/cvz227
Title: | Circles in the heart and cardiovascular system. | Authors: | LIM TINGSEN BENSON Lavenniah, Annadoray ROGER FOO SIK YIN |
Keywords: | Cardiovascular disease Circular RNA Gene therapy MicroRNA Non-coding RNAs |
Issue Date: | 25-Sep-2019 | Publisher: | Oxford University Press (OUP) | Citation: | LIM TINGSEN BENSON, Lavenniah, Annadoray, ROGER FOO SIK YIN (2019-09-25). Circles in the heart and cardiovascular system.. Cardiovasc Res. ScholarBank@NUS Repository. https://doi.org/10.1093/cvr/cvz227 | Abstract: | The combination of next-generation sequencing, advanced bioinformatics analysis, and molecular research has now established circular RNAs (circRNAs) as a heterogeneous group of non-coding RNA that is widely and abundantly expressed. CircRNAs are single-stranded RNA, covalently backspliced to form closed circular loops. Different models of back-splicing have been proposed, and mechanisms for circRNA function include sequestering microRNAs, direct interaction with proteins, regulation of transcription, and translation. Exploring the role of circRNAs in different disease settings, and understanding how they contribute to disease progression promises to provide valuable insight into potential novel therapeutic approaches. Here, we review the growing number of published research on circRNAs in the heart and cardiovascular system and summarize the circRNAs that have been implicated in disease. | Source Title: | Cardiovasc Res | URI: | https://scholarbank.nus.edu.sg/handle/10635/162088 | ISSN: | 0008-6363 1755-3245 |
DOI: | 10.1093/cvr/cvz227 |
Appears in Collections: | Staff Publications Elements |
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File | Description | Size | Format | Access Settings | Version | |
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Circles in the heart and cardiovascular system.pdf | 509.46 kB | Adobe PDF | CLOSED | Published | ||
190502 - Re-submitted (CVR-2019-0093_R2).pdf | 1.25 MB | Adobe PDF | OPEN | Post-print | View/Download |
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