Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0029250
Title: Seasonal variation in vitamin D 3 levels is paralleled by changes in the peripheral blood human T cell compartment
Authors: Khoo A.-L.
Koenen H.J.P.M.
Chai L.Y.A. 
Sweep F.C.G.J.
Netea M.G.
van der Ven A.J.A.M.
Joosten I.
Keywords: calcifediol
calcitriol
chemokine receptor CCR4
chemokine receptor CCR6
chemokine receptor CCR7
chemokine receptor CCR9
colecalciferol
cutaneous lymphocyte associated antigen
transcription factor FOXP3
colecalciferol
cytokine
adult
article
CD4+ T lymphocyte
CD8+ T lymphocyte
cell homing
controlled study
cytokine production
flow cytometry
human
human cell
lymphocyte count
lymphocyte migration
male
normal human
peripheral blood mononuclear cell
peripheral lymphocyte
protein expression
regulatory T lymphocyte
seasonal variation
T lymphocyte
vitamin blood level
autoimmune disease
biosynthesis
blood
cytology
environmental exposure
middle aged
mononuclear cell
radiation exposure
season
sunlight
T lymphocyte subpopulation
Adult
Autoimmune Diseases
Cholecalciferol
Cytokines
Environmental Exposure
Humans
Leukocytes, Mononuclear
Male
Middle Aged
Seasons
Sunlight
T-Lymphocyte Subsets
Issue Date: 2012
Citation: Khoo A.-L., Koenen H.J.P.M., Chai L.Y.A., Sweep F.C.G.J., Netea M.G., van der Ven A.J.A.M., Joosten I. (2012). Seasonal variation in vitamin D 3 levels is paralleled by changes in the peripheral blood human T cell compartment. PLoS ONE 7 (1) : e29250. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0029250
Rights: Attribution 4.0 International
Abstract: It is well-recognized that vitamin D 3 has immune-modulatory properties and that the variation in ultraviolet (UV) exposure affects vitamin D 3 status. Here, we investigated if and to what extent seasonality of vitamin D 3 levels are associated with changes in T cell numbers and phenotypes. Every three months during the course of the entire year, human PBMC and whole blood from 15 healthy subjects were sampled and analyzed using flow cytometry. We observed that elevated serum 25(OH)D 3 and 1,25(OH) 2 D 3 levels in summer were associated with a higher number of peripheral CD4 + and CD8 + T cells. In addition, an increase in naïve CD4 + CD45RA + T cells with a reciprocal drop in memory CD4 + CD45RO + T cells was observed. The increase in CD4 + CD45RA + T cell count was a result of heightened proliferative capacity rather than recent thymic emigration of T cells. The percentage of Treg dropped in summer, but not the absolute Treg numbers. Notably, in the Treg population, the levels of forkhead box protein 3 (Foxp3) expression were increased in summer. Skin, gut and lymphoid tissue homing potential was increased during summer as well, exemplified by increased CCR4, CCR6, CLA, CCR9 and CCR7 levels. Also, in summer, CD4 + and CD8 + T cells revealed a reduced capacity to produce pro-inflammatory cytokines. In conclusion, seasonal variation in vitamin D 3 status in vivo throughout the year is associated with changes in the human peripheral T cell compartment and may as such explain some of the seasonal variation in immune status which has been observed previously. Given that the current observations are limited to healthy adult males, larger population-based studies would be useful to validate these findings. © 2012 Khoo et al.
Source Title: PLoS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/162006
ISSN: 19326203
DOI: 10.1371/journal.pone.0029250
Rights: Attribution 4.0 International
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