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https://doi.org/10.1371/journal.pone.0030819
Title: | Mannose-binding Lectin 2 polymorphisms do not influence frequency or type of infection in adults with chemotherapy induced neutropaenia | Authors: | Wong M. Öhrmalm L. Broliden K. Aust C. Hibberd M. Tolfvenstam T. |
Keywords: | mannose binding lectin 2 antiinfective agent antineoplastic agent C reactive protein mannose binding lectin MBL2 protein, human article bacterial infection blood sampling controlled study cross-sectional study disease duration febrile neutropenia fever gene frequency genetic association genotype human infection sensitivity mannose binding lectin 2 gene mixed infection mutator gene neutropenia promoter region prospective study protein blood level single nucleotide polymorphism virus infection adult blood chemically induced disorder fever genetics infection metabolism microbiology neutropenia Sweden Adult Anti-Bacterial Agents Antineoplastic Agents C-Reactive Protein Fever Gene Frequency Genotype Humans Infection Mannose-Binding Lectin Neutropenia Polymorphism, Single Nucleotide Sweden |
Issue Date: | 2012 | Citation: | Wong M., Öhrmalm L., Broliden K., Aust C., Hibberd M., Tolfvenstam T. (2012). Mannose-binding Lectin 2 polymorphisms do not influence frequency or type of infection in adults with chemotherapy induced neutropaenia. PLoS ONE 7 (2) : e30819. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0030819 | Rights: | Attribution 4.0 International | Abstract: | Background: Mannose-binding Lectin protein (MBL) has been suggested to be relevant in the defence against infections in immunosuppressed individuals. In a Swedish adult cohort immunosuppressed from both the underlying disease and from iatrogenic treatments for their underlying disease we investigated the role of MBL in susceptibility to infection. Methods: In this cross sectional, prospective study, blood samples obtained from 96 neutropaenic febrile episodes, representing 82 individuals were analysed for single nucleotide polymorphism (SNP) in the MBL2 gene. Concurrent measurement of plasma MBL protein concentrations was also performed for observation of acute response during febrile episodes. Findings: No association was observed between MBL2 genotype or plasma MBL concentrations, and the type or frequency of infection. Adding to the literature, we found no evidence that viral infections or co-infections with virus and bacteria would be predisposed by MBL deficiency. We further saw no correlation between MBL2 genotype and the risk of fever. However, fever duration in febrile neutropaenic episodes was negatively associated with MBL2 SNP mutations (p<0.05). Patients with MBL2 SNP mutations presented a median febrile duration of 1.8 days compared with 3 days amongst patients with wildtype MBL2 genotype. Interpretation: We found no clear association between infection, or infection type to MBL2 genotypes or plasma MBL concentration, and add to the reports casting doubts on the benefit of recombinant MBL replacement therapy use during iatrogenic neutropaenia. © 2012 Wong et al. | Source Title: | PLoS ONE | URI: | https://scholarbank.nus.edu.sg/handle/10635/162000 | ISSN: | 19326203 | DOI: | 10.1371/journal.pone.0030819 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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