Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pntd.0004386
Title: Concerted Efforts to Control or Eliminate Neglected Tropical Diseases: How Much Health Will Be Gained?
Authors: de Vlas S.J.
Stolk W.A.
le Rutte E.A.
Hontelez J.A.C.
Bakker R.
Blok D.J.
Cai R.
Houweling T.A.J.
Kulik M.C.
Lenk E.J.
Luyendijk M.
Matthijsse S.M.
Redekop W.K. 
Wagenaar I.
Jacobson J.
Nagelkerke N.J.D.
Richardus J.H.
Keywords: African trypanosomiasis
Article
ascariasis
Chagas disease
death
disease control
health care concepts
health impact assessment
hookworm infection
incidence
leprosy
lymphatic filariasis
morbidity
mortality
neglected disease
onchocerciasis
prevalence
schistosomiasis
trachoma
trichuriasis
tropical disease
visceral leishmaniasis
years lived with disability
years of life lost
disease eradication
evaluation study
global health
human
Neglected Diseases
procedures
quality adjusted life year
tropical medicine
Disease Eradication
Global Health
Humans
Neglected Diseases
Quality-Adjusted Life Years
Tropical Medicine
Issue Date: 2016
Citation: de Vlas S.J., Stolk W.A., le Rutte E.A., Hontelez J.A.C., Bakker R., Blok D.J., Cai R., Houweling T.A.J., Kulik M.C., Lenk E.J., Luyendijk M., Matthijsse S.M., Redekop W.K., Wagenaar I., Jacobson J., Nagelkerke N.J.D., Richardus J.H. (2016). Concerted Efforts to Control or Eliminate Neglected Tropical Diseases: How Much Health Will Be Gained?. PLoS Neglected Tropical Diseases 10 (2) : e0004386. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pntd.0004386
Rights: Attribution 4.0 International
Abstract: Background: The London Declaration (2012) was formulated to support and focus the control and elimination of ten neglected tropical diseases (NTDs), with targets for 2020 as formulated by the WHO Roadmap. Five NTDs (lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminths and trachoma) are to be controlled by preventive chemotherapy (PCT), and four (Chagas? disease, human African trypanosomiasis, leprosy and visceral leishmaniasis) by innovative and intensified disease management (IDM). Guinea worm, virtually eradicated, is not considered here. We aim to estimate the global health impact of meeting these targets in terms of averted morbidity, mortality, and disability adjusted life years (DALYs). Methods: The Global Burden of Disease (GBD) 2010 study provides prevalence and burden estimates for all nine NTDs in 1990 and 2010, by country, age and sex, which were taken as the basis for our calculations. Estimates for other years were obtained by interpolating between 1990 (or the start-year of large-scale control efforts) and 2010, and further extrapolating until 2030, such that the 2020 targets were met. The NTD disease manifestations considered in the GBD study were analyzed as either reversible or irreversible. Health impacts were assessed by comparing the results of achieving the targets with the counterfactual, construed as the health burden had the 1990 (or 2010 if higher) situation continued unabated. Principle Findings/Conclusions: Our calculations show that meeting the targets will lead to about 600 million averted DALYs in the period 2011?2030, nearly equally distributed between PCT and IDM-NTDs, with the health gain amongst PCT-NTDs mostly (96%) due to averted disability and amongst IDM-NTDs largely (95%) from averted mortality. These health gains include about 150 million averted irreversible disease manifestations (e.g. blindness) and 5 million averted deaths. Control of soil-transmitted helminths accounts for one third of all averted DALYs. We conclude that the projected health impact of the London Declaration justifies the required efforts. ? 2016 de Vlas et al.
Source Title: PLoS Neglected Tropical Diseases
URI: https://scholarbank.nus.edu.sg/handle/10635/161922
ISSN: 19352727
DOI: 10.1371/journal.pntd.0004386
Rights: Attribution 4.0 International
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