Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pbio.2003167
Title: Bacterial deception of MAIT cells in a cloud of superantigen and cytokines
Authors: Sandberg J.K.
Norrby-Teglund A.
Leeansyah E. 
Keywords: bacterial antigen
cytokine
gamma interferon
hepatitis A virus cellular receptor 2
interleukin 12
interleukin 15
interleukin 17
interleukin 18
lymphocyte activation gene 3
major histocompatibility antigen class 1
major histocompatibility complex class Ib related protein 1
superantigen
tumor necrosis factor
unclassified drug
vitamin B group
cytokine
superantigen
bacterial immunity
cytokine storm
human
mucosal-associated invariant T cell
nonhuman
protein expression
protein function
Review
sepsis
Staphylococcus aureus
Streptococcus pyogenes
toxic shock syndrome
animal
biological model
cellular immunity
clonal anergy
immunology
lymphocyte activation
metabolism
microbiology
mucosal-associated invariant T cell
Staphylococcus aureus
T lymphocyte
Animals
Clonal Anergy
Cytokines
Humans
Immunity, Cellular
Lymphocyte Activation
Models, Immunological
Mucosal-Associated Invariant T Cells
Staphylococcus aureus
Superantigens
T-Lymphocytes
Issue Date: 2017
Citation: Sandberg J.K., Norrby-Teglund A., Leeansyah E. (2017). Bacterial deception of MAIT cells in a cloud of superantigen and cytokines. PLoS Biology 15 (7) : e2003167. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pbio.2003167
Abstract: The bacterium Staphylococcus aureus is an important cause of the life-threatening condition toxic shock syndrome in humans. Bacterial toxins known as superantigens (SAgs) generate this illness by acting as broad activators of a substantial fraction of all T lymphocytes, bypassing the normally highly stringent T-cell receptor antigen specificity to cause a systemic inflammatory cytokine storm in the host. In a new study, Shaler et al. found that immune cells called mucosa-associated invariant T (MAIT) cells make an unexpectedly large contribution to the SAg response in a largely T-cell receptor?independent, cytokine-driven manner. Subsequent to such activation, the MAIT cells remain unresponsive to stimulation with bacterial antigen. Thus, S. aureus hijacks MAIT cells in the cytokine storm and leaves them functionally impaired. This work provides new insight into the role of MAIT cells in antibacterial immunity and opens new avenues of investigation to understand and possibly treat bacterial toxic shock and sepsis. ? 2017 Sandberg et al.
Source Title: PLoS Biology
URI: https://scholarbank.nus.edu.sg/handle/10635/161892
ISSN: 15449173
DOI: 10.1371/journal.pbio.2003167
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