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https://doi.org/10.1371/journal.pgen.1007008
Title: | Analysis of nuclear and organellar genomes of Plasmodium knowlesi in humans reveals ancient population structure and recent recombination among host-specific subpopulations | Authors: | Diez Benavente E. Florez de Sessions P. Moon R.W. Holder A.A. Blackman M.J. Roper C. Drakeley C.J. Pain A. Sutherland C.J. Hibberd M.L. Campino S. Clark T.G. |
Keywords: | Article Borneo cell nucleus cell organelle chromosomal parameters chromosome 8 chromosome segment exchange deforestation genetic association genetic recombination genetic variation genotype habitat quality host parasite interaction Macaca fascicularis Macaca nemestrina Malaysia microbial genome nonhuman parasite isolation Plasmodium knowlesi population structure protein expression animal genetics genome host pathogen interaction human insect vector malaria mosquito parasitology pathogenicity Plasmodium knowlesi transmission Animals Culicidae Genome Host-Pathogen Interactions Humans Insect Vectors Macaca fascicularis Macaca nemestrina Malaria Organelles Plasmodium knowlesi |
Issue Date: | 2017 | Citation: | Diez Benavente E., Florez de Sessions P., Moon R.W., Holder A.A., Blackman M.J., Roper C., Drakeley C.J., Pain A., Sutherland C.J., Hibberd M.L., Campino S., Clark T.G. (2017). Analysis of nuclear and organellar genomes of Plasmodium knowlesi in humans reveals ancient population structure and recent recombination among host-specific subpopulations. PLoS Genetics 13 (9) : e1007008. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pgen.1007008 | Rights: | Attribution 4.0 International | Abstract: | The macaque parasite Plasmodium knowlesi is a significant concern in Malaysia where cases of human infection are increasing. Parasites infecting humans originate from genetically distinct subpopulations associated with the long-tailed (Macaca fascicularis (Mf)) or pig-tailed macaques (Macaca nemestrina (Mn)). We used a new high-quality reference genome to re-evaluate previously described subpopulations among human and macaque isolates from Malaysian-Borneo and Peninsular-Malaysia. Nuclear genomes were dimorphic, as expected, but new evidence of chromosomal-segment exchanges between subpopulations was found. A large segment on chromosome 8 originating from the Mn subpopulation and containing genes encoding proteins expressed in mosquito-borne parasite stages, was found in Mf genotypes. By contrast, non-recombining organelle genomes partitioned into 3 deeply branched lineages, unlinked with nuclear genomic dimorphism. Subpopulations which diverged in isolation have re-connected, possibly due to deforestation and disruption of wild macaque habitats. The resulting genomic mosaics reveal traits selected by host-vector-parasite interactions in a setting of ecological transition. ? 2017 Diez Benavente et al. | Source Title: | PLoS Genetics | URI: | https://scholarbank.nus.edu.sg/handle/10635/161890 | ISSN: | 15537390 | DOI: | 10.1371/journal.pgen.1007008 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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