Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0005946
Title: Cocaine modulates locomotion behavior in C. elegans
Authors: Ward A. 
Walker V.J.
Feng Z.
Xu X.Z.S.
Keywords: 4 aminobutyric acid
acetylcholine
cocaine
vesicular monoamine transporter
cocaine
dopamine uptake inhibitor
serotonin
animal experiment
article
Caenorhabditis elegans
concentration response
gene targeting
hyperactivity
locomotion
monoamine release
neuromodulation
nonhuman
serotoninergic system
serotoninergic transmission
stimulus response
allele
animal
animal behavior
automation
biological model
cocaine dependence
computer program
disease model
drug effect
genetics
movement (physiology)
mutation
pathophysiology
Caenorhabditis elegans
Mammalia
Alleles
Animals
Automation
Behavior, Animal
Caenorhabditis elegans
Cocaine
Cocaine-Related Disorders
Disease Models, Animal
Dopamine Uptake Inhibitors
Models, Biological
Movement
Mutation
Serotonin
Software
Issue Date: 2009
Citation: Ward A., Walker V.J., Feng Z., Xu X.Z.S. (2009). Cocaine modulates locomotion behavior in C. elegans. PLoS ONE 4 (6) : e5946. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0005946
Rights: Attribution 4.0 International
Abstract: Cocaine, a potent addictive substance, is an inhibitor of monoamine transporters, including DAT (dopamine transporter), SERT (serotonin transporter) and NET (norepinephrine transporter). Cocaine administration induces complex behavioral alterations in mammals, but the underlying mechanisms are not well understood. Here, we tested the effect of cocaine on C. elegans behavior. We show for the first time that acute cocaine treatment evokes changes in C. elegans locomotor activity. Interestingly, the neurotransmitter serotonin, rather than dopamine, is required for cocaine response in C. elegans. The C. elegans SERT MOD-5 is essential for the effect of cocaine, consistent with the role of cocaine in targeting monoamine transporters. We further show that the behavioral response to cocaine is primarily mediated by the ionotropic serotonin receptor MOD-1. Thus, cocaine modulates locomotion behavior in C. elegans primarily by impinging on its serotoninergic system. � 2009 Ward et al.
Source Title: PLoS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/161837
ISSN: 19326203
DOI: 10.1371/journal.pone.0005946
Rights: Attribution 4.0 International
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