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https://doi.org/10.1371/journal.pone.0005946
Title: | Cocaine modulates locomotion behavior in C. elegans | Authors: | Ward A. Walker V.J. Feng Z. Xu X.Z.S. |
Keywords: | 4 aminobutyric acid acetylcholine cocaine vesicular monoamine transporter cocaine dopamine uptake inhibitor serotonin animal experiment article Caenorhabditis elegans concentration response gene targeting hyperactivity locomotion monoamine release neuromodulation nonhuman serotoninergic system serotoninergic transmission stimulus response allele animal animal behavior automation biological model cocaine dependence computer program disease model drug effect genetics movement (physiology) mutation pathophysiology Caenorhabditis elegans Mammalia Alleles Animals Automation Behavior, Animal Caenorhabditis elegans Cocaine Cocaine-Related Disorders Disease Models, Animal Dopamine Uptake Inhibitors Models, Biological Movement Mutation Serotonin Software |
Issue Date: | 2009 | Citation: | Ward A., Walker V.J., Feng Z., Xu X.Z.S. (2009). Cocaine modulates locomotion behavior in C. elegans. PLoS ONE 4 (6) : e5946. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0005946 | Rights: | Attribution 4.0 International | Abstract: | Cocaine, a potent addictive substance, is an inhibitor of monoamine transporters, including DAT (dopamine transporter), SERT (serotonin transporter) and NET (norepinephrine transporter). Cocaine administration induces complex behavioral alterations in mammals, but the underlying mechanisms are not well understood. Here, we tested the effect of cocaine on C. elegans behavior. We show for the first time that acute cocaine treatment evokes changes in C. elegans locomotor activity. Interestingly, the neurotransmitter serotonin, rather than dopamine, is required for cocaine response in C. elegans. The C. elegans SERT MOD-5 is essential for the effect of cocaine, consistent with the role of cocaine in targeting monoamine transporters. We further show that the behavioral response to cocaine is primarily mediated by the ionotropic serotonin receptor MOD-1. Thus, cocaine modulates locomotion behavior in C. elegans primarily by impinging on its serotoninergic system. � 2009 Ward et al. | Source Title: | PLoS ONE | URI: | https://scholarbank.nus.edu.sg/handle/10635/161837 | ISSN: | 19326203 | DOI: | 10.1371/journal.pone.0005946 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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