Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0107306
Title: Disrupted brain functional network in internet addiction disorder: A resting-state functional magnetic resonance imaging study
Authors: Wee C.Y. 
Zhao Z.
Yap P.T.
Wu G.
Shi F.
Price T.
Du Y.
Xu J.
Zhou Y.
Shen D.
Keywords: adolescent
Article
brain function
brain region
clinical article
connectome
controlled study
female
functional magnetic resonance imaging
functional neuroimaging
hemisphere
human
internet addiction
male
neuropathology
resting state network
addiction
brain
brain mapping
case control study
Internet
nuclear magnetic resonance imaging
pathophysiology
rest
young adult
Adolescent
Behavior, Addictive
Brain
Brain Mapping
Case-Control Studies
Female
Humans
Internet
Magnetic Resonance Imaging
Male
Rest
Young Adult
Issue Date: 2014
Citation: Wee C.Y., Zhao Z., Yap P.T., Wu G., Shi F., Price T., Du Y., Xu J., Zhou Y., Shen D. (2014). Disrupted brain functional network in internet addiction disorder: A resting-state functional magnetic resonance imaging study. PLoS ONE 9 (9) : e107306. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0107306
Abstract: Internet addiction disorder (IAD) is increasingly recognized as a mental health disorder, particularly among adolescents. The pathogenesis associated with IAD, however, remains unclear. In this study, we aim to explore the encephalic functional characteristics of IAD adolescents at rest using functional magnetic resonance imaging data. We adopted a graph-theoretic approach to investigate possible disruptions of functional connectivity in terms of network properties including small-worldness, efficiency, and nodal centrality on 17 adolescents with IAD and 16 socio-demographically matched healthy controls. False discovery rate-corrected parametric tests were performed to evaluate the statistical significance of grouplevel network topological differences. In addition, a correlation analysis was performed to assess the relationships between functional connectivity and clinical measures in the IAD group. Our results demonstrate that there is significant disruption in the functional connectome of IAD patients, particularly between regions located in the frontal, occipital, and parietal lobes. The affected connections are long-range and inter-hemispheric connections. Although significant alterations are observed for regional nodal metrics, there is no difference in global network topology between IAD and healthy groups. In addition, correlation analysis demonstrates that the observed regional abnormalities are correlated with the IAD severity and behavioral clinical assessments. Our findings, which are relatively consistent between anatomically and functionally defined atlases, suggest that IAD causes disruptions of functional connectivity and, importantly, that such disruptions might link to behavioral impairments. © 2014 PLOS ONE.
Source Title: PLoS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/161773
ISSN: 19326203
DOI: 10.1371/journal.pone.0107306
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