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https://doi.org/10.1371/journal.pone.0111045
Title: | A panel of overexpressed proteins for prognosis in esophageal squamous cell carcinoma | Authors: | Shang L. Liu H.-J. Hao J.-J. Jiang Y.-Y. Shi F. Zhang Y. Cai Y. Xu X. Jia X.-M. Zhan Q.-M. Wang M.-R. |
Keywords: | epidermal growth factor receptor phosphatidylinositol 3 kinase phosphatidylinositol 3 kinase p110alpha phosphatidylinositol 3 kinase p85alpha protein p53 stem cell factor receptor tissue inhibitor of metalloproteinase 1 unclassified drug EGFR protein, human epidermal growth factor receptor phosphatidylinositol 4,5 bisphosphate 3 kinase protein p53 stem cell factor receptor TIMP1 protein, human tissue inhibitor of metalloproteinase 1 TP53 protein, human tumor marker adult aged Article cancer prognosis controlled study esophageal squamous cell carcinoma female human human tissue immunohistochemistry major clinical study male overall survival protein expression Carcinoma, Squamous Cell Esophageal Neoplasms Kaplan Meier method metabolism middle aged mortality prognosis proportional hazards model Carcinoma, Squamous Cell Class Ia Phosphatidylinositol 3-Kinase Esophageal Neoplasms Female Humans Kaplan-Meier Estimate Male Middle Aged Prognosis Proportional Hazards Models Proto-Oncogene Proteins c-kit Receptor, Epidermal Growth Factor Tissue Inhibitor of Metalloproteinase-1 Tumor Markers, Biological Tumor Suppressor Protein p53 |
Issue Date: | 2014 | Citation: | Shang L., Liu H.-J., Hao J.-J., Jiang Y.-Y., Shi F., Zhang Y., Cai Y., Xu X., Jia X.-M., Zhan Q.-M., Wang M.-R. (2014). A panel of overexpressed proteins for prognosis in esophageal squamous cell carcinoma. PLoS ONE 9 (10) : A1827. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0111045 | Rights: | Attribution 4.0 International | Abstract: | Esophageal squamous cell carcinoma (ESCC) is a common cancer with poor prognosis. In order to identify useful biomarkers for accurately classifying prognostic risks for ESCC patients, we examined the expression of six proteins by immunohistochemistry (IHC) in 590 paraffin-embedded ESCC samples. The candidate proteins include p53, EGFR, c-KIT, TIMP1 and PI3K-p110a reported to be altered in ESCC tissues as well as another important component of PI3K, PI3K-p85a. Of the six proteins tested, p53, EGFR, c-KIT, TIMP1 and PI3K-p85a were detected with high expression in 43.0%, 36.6%, 55.9%, 70.7% and 57.1% of tumors, respectively. Significant associations were found between high expression of PI3K-p85a, EGFR and p53 and poor prognosis (P = 0.00111;0.00001;0.00426). Applying these three proteins as an IHC panel could divide patients into different subgroups (P<0.000001). Multivariate cox regression analysis indicated that the three-protein panel was an independent prognostic factor with very high statistical significance (HR = 2.090, 95% CI: 1.621-2.696, P = 0.00000001). The data suggest that the three-protein panel of PI3K-p85a, EGFR and p53 is an important candidate biomarker for the prognosis of patients with ESCC. Copyright: © 2014 Shang et al. | Source Title: | PLoS ONE | URI: | https://scholarbank.nus.edu.sg/handle/10635/161765 | ISSN: | 19326203 | DOI: | 10.1371/journal.pone.0111045 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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