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https://doi.org/10.1371/journal.pone.0144260
Title: | Relationship between Blood Pressure and Outcomes in Acute Ischemic Stroke Patients Administered Lytic Medication in the TIMSChina Study | Authors: | Wu W. Huo X. Zhao X. Liao X. Wang C. Pan Y. Wang Y. Wang Y. Wang C. Liu L. Bi Q. Cui L. Sun Y. He M. Fan D. Zhang X. Li Y. Wang S. Fan W. Ren C. Liu Z. Sun X. Chen X. Bai Q. Gu D. Hu C. Li X. Dong Q. Cheng Y. Li B. Li C. Wang T. Wang L. Zhao K. Tao D. Qu F. Zhang J. Wang J. Lian Y. Gao Y. Sun H. Li J. Li G. Zhu Y. Yang Z. Zhou J. Guo M. Ma Q. Gao X. Huang R. Xiao B. Chen K. Gao L. Xu A. Shao M. Xu E. Pan X. Cai Y. Xu Y. Ke K. Kong Y. Ding L. Cao Y. Liu Y. Xu K. Xing C. Su S. Zhang G. Zheng R. Zhai M. Zhu Y. Liu Y. Zhang X. Wu S. Liu J. |
Keywords: | alteplase tissue plasminogen activator adult aged Article blood clot lysis brain hemorrhage brain ischemia China controlled clinical trial controlled study diastolic blood pressure drug efficacy drug safety female human major clinical study male multicenter study observational study open study prospective study Rankin scale symptomatic intracerebral hemorrhage symptomatic intracerebral hemorrhage systolic blood pressure treatment outcome blood pressure brain ischemia clinical trial complication fibrinolytic therapy middle aged pathophysiology Stroke systole time factor treatment outcome Aged Blood Pressure Brain Ischemia China Female Humans Male Middle Aged Stroke Systole Thrombolytic Therapy Time Factors Tissue Plasminogen Activator Treatment Outcome |
Issue Date: | 2016 | Citation: | Wu W., Huo X., Zhao X., Liao X., Wang C., Pan Y., Wang Y., Wang Y., Wang C., Liu L., Bi Q., Cui L., Sun Y., He M., Fan D., Zhang X., Li Y., Wang S., Fan W., Ren C., Liu Z., Sun X., Chen X., Bai Q., Gu D., Hu C., Li X., Dong Q., Cheng Y., Li B., Li C., Wang T., Wang L., Zhao K., Tao D., Qu F., Zhang J., Wang J., Lian Y., Gao Y., Sun H., Li J., Li G., Zhu Y., Yang Z., Zhou J., Guo M., Ma Q., Gao X., Huang R., Xiao B., Chen K., Gao L., Xu A., Shao M., Xu E., Pan X., Cai Y., Xu Y., Ke K., Kong Y., Ding L., Cao Y., Liu Y., Xu K., Xing C., Su S., Zhang G., Zheng R., Zhai M., Zhu Y., Liu Y., Zhang X., Wu S., Liu J. (2016). Relationship between Blood Pressure and Outcomes in Acute Ischemic Stroke Patients Administered Lytic Medication in the TIMSChina Study. PLoS ONE 11 (2) : e0144260. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0144260 | Rights: | Attribution 4.0 International | Abstract: | Objective Increased blood pressure (BP) management following acute ischemic stroke (AIS) remains controversial. This study aimed to identify the association between BP and clinical outcomes in AIS patients administered lytic medication in the TIMS-China (thrombolysis implementation and monitor of acute ischemic stroke in China) database. Methods The sample comprised 1128 patients hospitalized within 4.5 hours (h) of AIS for intravenous recombinant tissue plasminogen activator (i.v. rt-PA) thrombolysis. Systolic BP (SBP) and diastolic BP (DBP) at baseline, 2 h and 24 h after treatment, and changes from baseline were analyzed. The study outcomes comprised a favorable outcome (modified Rankin Scale 0-1 at 90 days) and symptomatic intracerebral hemorrhage (SICH), analyzed using logistic regression, with low BP as the reference group. Results Lower BP (baseline, 2 h, and 24 h) was beneficial in AIS patients and significantly related to a favorable outcome (Poutcome (P<0.05). A substantial BP decrease at 24 h after rt-PA thrombolysis was significantly associated with a favorable outcome compared with a moderate BP decrease (P = 0.0298). A SBP >160 mmHg 2 h after rt-PA thrombolysis was significantly associated with SICH compared with a SBP <140 mmHg (P = 0.0238). An increase or no change (>25 mmHg) in SBP was significantly associated with SICH (P = 0.002) compared with a small SBP decrease (1-9 mmHg). � 2016 Wu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | Source Title: | PLoS ONE | URI: | https://scholarbank.nus.edu.sg/handle/10635/161588 | ISSN: | 19326203 | DOI: | 10.1371/journal.pone.0144260 | Rights: | Attribution 4.0 International |
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