Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0144260
Title: Relationship between Blood Pressure and Outcomes in Acute Ischemic Stroke Patients Administered Lytic Medication in the TIMSChina Study
Authors: Wu W.
Huo X.
Zhao X.
Liao X.
Wang C.
Pan Y.
Wang Y.
Wang Y.
Wang C.
Liu L.
Bi Q.
Cui L.
Sun Y.
He M.
Fan D.
Zhang X.
Li Y.
Wang S.
Fan W.
Ren C.
Liu Z.
Sun X.
Chen X.
Bai Q.
Gu D.
Hu C.
Li X.
Dong Q.
Cheng Y.
Li B.
Li C.
Wang T.
Wang L.
Zhao K.
Tao D.
Qu F.
Zhang J.
Wang J.
Lian Y.
Gao Y.
Sun H.
Li J.
Li G.
Zhu Y.
Yang Z.
Zhou J.
Guo M.
Ma Q.
Gao X.
Huang R.
Xiao B. 
Chen K.
Gao L.
Xu A.
Shao M.
Xu E.
Pan X.
Cai Y.
Xu Y.
Ke K.
Kong Y.
Ding L.
Cao Y.
Liu Y.
Xu K.
Xing C.
Su S.
Zhang G.
Zheng R.
Zhai M.
Zhu Y.
Liu Y.
Zhang X.
Wu S.
Liu J.
Keywords: alteplase
tissue plasminogen activator
adult
aged
Article
blood clot lysis
brain hemorrhage
brain ischemia
China
controlled clinical trial
controlled study
diastolic blood pressure
drug efficacy
drug safety
female
human
major clinical study
male
multicenter study
observational study
open study
prospective study
Rankin scale
symptomatic intracerebral hemorrhage
symptomatic intracerebral hemorrhage
systolic blood pressure
treatment outcome
blood pressure
brain ischemia
clinical trial
complication
fibrinolytic therapy
middle aged
pathophysiology
Stroke
systole
time factor
treatment outcome
Aged
Blood Pressure
Brain Ischemia
China
Female
Humans
Male
Middle Aged
Stroke
Systole
Thrombolytic Therapy
Time Factors
Tissue Plasminogen Activator
Treatment Outcome
Issue Date: 2016
Citation: Wu W., Huo X., Zhao X., Liao X., Wang C., Pan Y., Wang Y., Wang Y., Wang C., Liu L., Bi Q., Cui L., Sun Y., He M., Fan D., Zhang X., Li Y., Wang S., Fan W., Ren C., Liu Z., Sun X., Chen X., Bai Q., Gu D., Hu C., Li X., Dong Q., Cheng Y., Li B., Li C., Wang T., Wang L., Zhao K., Tao D., Qu F., Zhang J., Wang J., Lian Y., Gao Y., Sun H., Li J., Li G., Zhu Y., Yang Z., Zhou J., Guo M., Ma Q., Gao X., Huang R., Xiao B., Chen K., Gao L., Xu A., Shao M., Xu E., Pan X., Cai Y., Xu Y., Ke K., Kong Y., Ding L., Cao Y., Liu Y., Xu K., Xing C., Su S., Zhang G., Zheng R., Zhai M., Zhu Y., Liu Y., Zhang X., Wu S., Liu J. (2016). Relationship between Blood Pressure and Outcomes in Acute Ischemic Stroke Patients Administered Lytic Medication in the TIMSChina Study. PLoS ONE 11 (2) : e0144260. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0144260
Rights: Attribution 4.0 International
Abstract: Objective Increased blood pressure (BP) management following acute ischemic stroke (AIS) remains controversial. This study aimed to identify the association between BP and clinical outcomes in AIS patients administered lytic medication in the TIMS-China (thrombolysis implementation and monitor of acute ischemic stroke in China) database. Methods The sample comprised 1128 patients hospitalized within 4.5 hours (h) of AIS for intravenous recombinant tissue plasminogen activator (i.v. rt-PA) thrombolysis. Systolic BP (SBP) and diastolic BP (DBP) at baseline, 2 h and 24 h after treatment, and changes from baseline were analyzed. The study outcomes comprised a favorable outcome (modified Rankin Scale 0-1 at 90 days) and symptomatic intracerebral hemorrhage (SICH), analyzed using logistic regression, with low BP as the reference group. Results Lower BP (baseline, 2 h, and 24 h) was beneficial in AIS patients and significantly related to a favorable outcome (Poutcome (P<0.05). A substantial BP decrease at 24 h after rt-PA thrombolysis was significantly associated with a favorable outcome compared with a moderate BP decrease (P = 0.0298). A SBP >160 mmHg 2 h after rt-PA thrombolysis was significantly associated with SICH compared with a SBP <140 mmHg (P = 0.0238). An increase or no change (>25 mmHg) in SBP was significantly associated with SICH (P = 0.002) compared with a small SBP decrease (1-9 mmHg). � 2016 Wu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Source Title: PLoS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/161588
ISSN: 19326203
DOI: 10.1371/journal.pone.0144260
Rights: Attribution 4.0 International
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