Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0161098
Title: First post-operative urinary kidney injury biomarkers and association with the duration of AKI in the TRIBE-AKI cohort
Authors: Coca S.G.
Nadkarni G.N.
Garg A.X.
Koyner J.
Thiessen-Philbrook H.
McArthur E.
Shlipak M.G.
Parikh C.R.
Raman J. 
Jeevanandam V.
Akhter S.
Edelstein C.
Passik C.
Nagy J.
Swaminathan M.
Chu M.
Goldbach M.
Guo L.R.
McKenzie N.
Myers M.L.
Novick R.
Quantz M.
Zappitelli M.
Palijan A.
Dewar M.
Darr U.
Hashim S.
Elefteriades J.
Geirsson A.
Garwood S.
Butrymowicz I.
Krumholz H.
Keywords: albumin
biological marker
creatinine
fatty acid binding protein
interleukin 18
kidney injury molecule 1
neutrophil gelatinase associated lipocalin
biological marker
creatinine
FABP1 protein, human
fatty acid binding protein
HAVCR1 protein, human
interleukin 18
kidney injury molecule 1
neutrophil gelatinase associated lipocalin
acute kidney failure
adult
aged
albumin urine level
Article
cohort analysis
comorbidity
controlled clinical trial
controlled study
creatinine blood level
disease association
disease duration
disease severity
female
follow up
glomerulus filtration rate
heart surgery
high risk patient
human
major clinical study
male
medical history
mortality rate
multicenter study
postoperative period
prospective study
protein urine level
urinalysis
urine level
Acute Kidney Injury
adverse effects
albuminuria
blood
mortality
prognosis
time factor
urine
Acute Kidney Injury
Aged
Albuminuria
Biomarkers
Cardiac Surgical Procedures
Creatinine
Fatty Acid-Binding Proteins
Female
Hepatitis A Virus Cellular Receptor 1
Humans
Interleukin-18
Lipocalin-2
Male
Prognosis
Prospective Studies
Time Factors
Issue Date: 2016
Citation: Coca S.G., Nadkarni G.N., Garg A.X., Koyner J., Thiessen-Philbrook H., McArthur E., Shlipak M.G., Parikh C.R., Raman J., Jeevanandam V., Akhter S., Edelstein C., Passik C., Nagy J., Swaminathan M., Chu M., Goldbach M., Guo L.R., McKenzie N., Myers M.L., Novick R., Quantz M., Zappitelli M., Palijan A., Dewar M., Darr U., Hashim S., Elefteriades J., Geirsson A., Garwood S., Butrymowicz I., Krumholz H. (2016). First post-operative urinary kidney injury biomarkers and association with the duration of AKI in the TRIBE-AKI cohort. PLoS ONE 11 (8) : e0161098. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0161098
Rights: Attribution 4.0 International
Abstract: Background: We previously demonstrated that assessment of the duration of AKI, in addition to magnitude of rise in creatinine alone, adds prognostic information for long-term survival. We evaluated whether post-operative kidney injury biomarkers in urine collected immediately after cardiac surgery associate with duration of serum creatinine elevation. Methods: We studied 1199 adults undergoing cardiac surgery in a prospective cohort study (TRIBEAKI) and examined the association between the levels of five urinary biomarkers individually at 0-6 hours after surgery: interleukin-18 (IL-18), neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), liver fatty acid binding protein (L-FABP) and albumin with duration of serum creatinine-based AKIN criteria for AKI (0 (no AKI), 1-2, 3-6, >7 days). Results: Overall, 407 (34%) patients had at least stage 1 AKI, of whom 251 (61.7%) had duration of 1-2 days, 118 (28.9%) had duration 3-6 days, and 38 (9.3%) had duration of >7 days. Higher concentrations of all biomarkers (per log increase) were independently associated with a greater odds of a longer duration of AKI; odds ratios and 95%confidence intervals using ordinal logistic regression were the following: IL-18: 1.22, 1.13-1.32; KIM-1: 1.36, 1.21-1.52; albumin 1.20, 1.09-1.32; L-FABP 1.11, 1.04-1.19; NGAL 1.06, 1.00-1.14). AKI duration of 7 days or longer was associated with a 5-fold adjusted risk of mortality at 3 years. Conclusions: There was an independent dose-response association between urinary levels of injury biomarkers immediately after cardiac surgery and longer duration of AKI. Duration of AKI was also associated with long term mortality. Future studies should explore the potential utility of these urinary kidney injury biomarkers to enrich enrollment of patients at risk for longer duration of AKI into trials of interventions to prevent or treat post-operative AKI. © 2016 Coca et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Source Title: PLoS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/161561
ISSN: 19326203
DOI: 10.1371/journal.pone.0161098
Rights: Attribution 4.0 International
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