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Title: Hemodynamics in coronary arterial tree of serial stenoses
Authors: Chen X.
Gao Y.
Lu B.
Jia X.
Zhong L. 
Kassab G.S.
Tan W.
Huo Y.
Keywords: Article
cardiovascular parameters
computed tomographic angiography
computed tomography scanner
contrast enhancement
controlled study
coronary artery obstruction
heart hemodynamics
left anterior descending coronary artery
oscillatory shear index
outlet flow resistance
pulse wave
retrospective study
shear stress
time averaged wall shear stress
Issue Date: 2016
Citation: Chen X., Gao Y., Lu B., Jia X., Zhong L., Kassab G.S., Tan W., Huo Y. (2016). Hemodynamics in coronary arterial tree of serial stenoses. PLoS ONE 11 (9) : e0163715. ScholarBank@NUS Repository.
Abstract: Serial segmental narrowing frequently occurs in humans, which alters coronary hemodynamics and further affects atherosclerotic progression and plaque formation. The objective of this study was to understand the distribution of hemodynamic parameters in the epicardial left main coronary arterial (LMCA) tree with serial stenoses reconstructed from patient computer tomography angiography (CTA) images. A finite volume method was used in conjunction with the inlet pressure wave and outlet flow resistance. The time-averaged wall shear stress (TAWSS) and oscillatory shear index (OSI) were determined from the flow field. A stenosis at a mother vessel mainly deteriorated the hemodynamics near the bifurcation while a stenosis at a daughter vessel affected the remote downstream bifurcation. In comparison with a single stenosis, serial stenoses increased the peak pressure gradient along the main trunk of the epicardial left anterior descending arterial tree by > 50%. An increased distance between serial stenoses further increased the peak pressure gradient. These findings have important implications on the diagnosis and treatment of serial coronary stenoses. � 2016 Chen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Source Title: PLoS ONE
ISSN: 19326203
DOI: 10.1371/journal.pone.0163715
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