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https://doi.org/10.1371/journal.pone.0051198
Title: | Analysis of Genome-Wide Association Studies with Multiple Outcomes Using Penalization | Authors: | Liu J. Huang J. Ma S. |
Keywords: | analytic method article CD3+ T lymphocyte CD4 CD8 ratio classification algorithm correlation analysis gene frequency genetic analysis genetic association genetic database genotype mathematical analysis mathematical computing multivariate analysis of variance penalization phenotype simulation single nucleotide polymorphism Algorithms Animals Computer Simulation Databases, Genetic Genetic Markers Genetic Predisposition to Disease Genetic Techniques Genome-Wide Association Study Humans Linear Models Mice Models, Genetic Models, Statistical Multivariate Analysis Phenotype Regression Analysis Risk Factors Mus |
Issue Date: | 2012 | Citation: | Liu J., Huang J., Ma S. (2012). Analysis of Genome-Wide Association Studies with Multiple Outcomes Using Penalization. PLoS ONE 7 (12) : e51198. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0051198 | Rights: | Attribution 4.0 International | Abstract: | Genome-wide association studies have been extensively conducted, searching for markers for biologically meaningful outcomes and phenotypes. Penalization methods have been adopted in the analysis of the joint effects of a large number of SNPs (single nucleotide polymorphisms) and marker identification. This study is partly motivated by the analysis of heterogeneous stock mice dataset, in which multiple correlated phenotypes and a large number of SNPs are available. Existing penalization methods designed to analyze a single response variable cannot accommodate the correlation among multiple response variables. With multiple response variables sharing the same set of markers, joint modeling is first employed to accommodate the correlation. The group Lasso approach is adopted to select markers associated with all the outcome variables. An efficient computational algorithm is developed. Simulation study and analysis of the heterogeneous stock mice dataset show that the proposed method can outperform existing penalization methods. © 2012 Liu et al. | Source Title: | PLoS ONE | URI: | https://scholarbank.nus.edu.sg/handle/10635/161360 | ISSN: | 19326203 | DOI: | 10.1371/journal.pone.0051198 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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