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Title: | HACEK Infective Endocarditis: Characteristics and Outcomes from a Large, Multi-National Cohort | Authors: | Chambers S.T. Murdoch D. Morris A. Holland D. Pappas P. Almela M. Fernández-Hidalgo N. Almirante B. Bouza E. Forno D. Rio A. Hannan M.M. Harkness J. Kanafani Z.A. Lalani T. Lang S. Raymond N. Read K. Vinogradova T. Woods C.W. Wray D. Corey G.R. Chu V.H. Clara L. Sanchez M. Nacinovich F. Oses P.F. Ronderos R. Sucari A. Thierer J. Casabé J. Cortes C. Altclas J. Silvia Kogan S. Spelman D. Athan E. Harris O. Kennedy K. Tan R. Gordon D. Papanicolas L. Eisen D. Grigg L. Street A. Korman T. Kotsanas D. Dever R. Jones P. Konecny P. Lawrence R. Rees D. Ryan S. Feneley M.P. Harkness J. Jones P. Ryan S. Jones P. Ryan S. Jones P. Post J. Reinbott P. Ryan S. Gattringer R. Wiesbauer F. Andrade A.R. de Brito A.C.P. Guimarães A.C. Grinberg M. Mansur A.J. Siciliano R.F. Strabelli T.M.V. Vieira M.L.C. de Medeiros Tranchesi R.A. Paiva M.G. Fortes C.Q. de Oliveira Ramos A. Ferraiuoli G. Golebiovski W. Lamas C. Santos M. Weksler C. Karlowsky J.A. Keynan Y. Morris A.M. Rubinstein E. Jones S.B. Garcia P. Cereceda M. Fica A. Mella R.M. Barsic B. Bukovski S. Krajinovic V. Pangercic A. Rudez I. Vincelj J. Freiberger T. Pol J. Zaloudikova B. Ashour Z. Kholy A.E. Mishaal M. Rizk H. Aissa N. Alauzet C. Alla F. Campagnac C. Doco-Lecompte T. Selton-Suty C. Casalta J.-P. Fournier P.-E. Habib G. Raoult D. Thuny F. Delahaye F. Delahaye A. Vandenesch F. Donal E. Donnio P.Y. Michelet C. Revest M. Tattevin P. Violette J. Chevalier F. Jeu A. Rusinaru D.M.D. Sorel C. Tribouilloy C. Bernard Y. Chirouze C. Hoen B. Leroy J. Plesiat P. Naber C. Neuerburg C. Mazaheri B. Neuerburg C. Athanasia S. Giannitsioti E. Mylona E. Paniara O. Papanicolaou K. Pyros J. Skoutelis A. Sharma G. Francis J. Nair L. Thomas V. Venugopal K. Hannan M. Hurley J. Gilon D. Israel S. Korem M. Strahilevitz J. Rubinstein E. Strahilevitz J. Tripodi M.F. Casillo R. Cuccurullo S. Dialetto G. Durante-Mangoni E. Irene M. Ragone E. Utili R. Cecchi E. De Rosa F. Forno D. Imazio M. Trinchero R. Tebini A. Grossi P. Lattanzio M. Toniolo A. Goglio A. Raglio A. Ravasio V. Rizzi M. Suter F. Carosi G. Magri S. Signorini L. Baban T. Kanafani Z. Kanj S.S. Sfeir J. Yasmine M. Abidin I. Tamin S.S. Martínez E.R. Nieto G.I.S. van der Meer J.T.M. Chambers S. Holland D. Morris A. Raymond N. Read K. Murdoch D.R. Dragulescu S. Ionac A. Mornos C. Butkevich O.M. Chipigina N. Kirill O. Vadim K. Vinogradova T. Edathodu J. Halim M. Lum L.-N. Tan R.-S. Lejko-Zupanc T. Logar M. Mueller-Premru M. Commerford P. Commerford A. Deetlefs E. Hansa C. Ntsekhe M. Almela M. Armero Y. Azqueta M. Castañeda X. Cervera C. Rio A. Falces C. Garcia-de-la-Maria C. Fita G. Gatell J.M. Marco F. Mestres C.A. Miró J.M. Moreno A. Ninot S. Paré C. Pericas J. Ramirez J. Rovira I. Sitges M. Anguera I. Font B. Guma J.R. Bermejo J. Bouza E. Fernández M.A.G. Gonzalez-Ramallo V. Marín M. Muñoz P. Pedromingo M. Roda J. Rodríguez-Créixems M. Solis J. Almirante B. Fernandez-Hidalgo N. Tornos P. de Alarcón A. Parra R. Alestig E. Johansson M. Olaison L. Snygg-Martin U. Pachirat O. Pachirat P. Pussadhamma B. Senthong V. Casey A. Elliott T. Lambert P. Watkin R. Eyton C. Klein J.L. Bradley S. Kauffman C. Bedimo R. Chu V.H. Corey G.R. Crowley A.L. Douglas P. Drew L. Fowler V.G. Holland T. Lalani T. Mudrick D. Samad Z. Sexton D. Stryjewski M. Wang A. Woods C.W. Lerakis S. Cantey R. Steed L. Wray D. Dickerman S.A. Bonilla H. DiPersio J. Salstrom S.-J. Baddley J. Patel M. Peterson G. Stancoven A. Afonso L. Kulman T. Levine D. Rybak M. Cabell C.H. Baloch K. Chu V.H. Corey G.R. Dixon C.C. Fowler Jr. V.G. Harding T. Jones-Richmond M. Pappas P. Park L.P. Redick T. Stafford J. Anstrom K. Athan E. Bayer A.S. Cabell C.H. Chu V.H. Hoen B. Karchmer A.W. Murdoch D.R. Sexton D.J. Wang A. Bayer A.S. Cabell C.H. Chu V. Durack D.T. Eykyn S. Hoen B. Moreillon P. Olaison L. Raoult D. Rubinstein E. |
Keywords: | aminoglycoside ampicillin cefalotin cefazolin ceftriaxone gentamicin penicillin G penicillinase adult Africa age Aggregatibacter antimicrobial therapy aorta valve prosthesis article Asia Australia bacterial endocarditis Cardiobacterium hominis cerebrovascular accident congenital heart disease congestive heart failure controlled study diabetes mellitus disease association Eikenella corrodens endocarditis Europe female follow up Haemophilus heart murmur heart surgery heart valve regurgitation hospitalization human immunology Kingella major clinical study male Middle East mitral valve disease mortality native valve endocarditis New Zealand North America outcome assessment prevalence prosthetic valve endocarditis South America Aggregatibacter Cardiobacterium cohort analysis Eikenella corrodens Endocarditis, Bacterial Haemophilus Kingella microbiology nonparametric test pathophysiology risk treatment outcome Age Factors Aggregatibacter Cardiobacterium Cohort Studies Eikenella corrodens Endocarditis, Bacterial Haemophilus Humans Kingella Odds Ratio Prevalence Statistics, Nonparametric Treatment Outcome |
Issue Date: | 2013 | Citation: | Chambers S.T., Murdoch D., Morris A., Holland D., Pappas P., Almela M., Fernández-Hidalgo N., Almirante B., Bouza E., Forno D., Rio A., Hannan M.M., Harkness J., Kanafani Z.A., Lalani T., Lang S., Raymond N., Read K., Vinogradova T., Woods C.W., Wray D., Corey G.R., Chu V.H., Clara L., Sanchez M., Nacinovich F., Oses P.F., Ronderos R., Sucari A., Thierer J., Casabé J., Cortes C., Altclas J., Silvia Kogan S., Spelman D., Athan E., Harris O., Kennedy K., Tan R., Gordon D., Papanicolas L., Eisen D., Grigg L., Street A., Korman T., Kotsanas D., Dever R., Jones P., Konecny P., Lawrence R., Rees D., Ryan S., Feneley M.P., Harkness J., Jones P., Ryan S., Jones P., Ryan S., Jones P., Post J., Reinbott P., Ryan S., Gattringer R., Wiesbauer F., Andrade A.R., de Brito A.C.P., Guimarães A.C., Grinberg M., Mansur A.J., Siciliano R.F., Strabelli T.M.V., Vieira M.L.C., de Medeiros Tranchesi R.A., Paiva M.G., Fortes C.Q., de Oliveira Ramos A., Ferraiuoli G., Golebiovski W., Lamas C., Santos M., Weksler C., Karlowsky J.A., Keynan Y., Morris A.M., Rubinstein E., Jones S.B., Garcia P., Cereceda M., Fica A., Mella R.M., Barsic B., Bukovski S., Krajinovic V., Pangercic A., Rudez I., Vincelj J., Freiberger T., Pol J., Zaloudikova B., Ashour Z., Kholy A.E., Mishaal M., Rizk H., Aissa N., Alauzet C., Alla F., Campagnac C., Doco-Lecompte T., Selton-Suty C., Casalta J.-P., Fournier P.-E., Habib G., Raoult D., Thuny F., Delahaye F., Delahaye A., Vandenesch F., Donal E., Donnio P.Y., Michelet C., Revest M., Tattevin P., Violette J., Chevalier F., Jeu A., Rusinaru D.M.D., Sorel C., Tribouilloy C., Bernard Y., Chirouze C., Hoen B., Leroy J., Plesiat P., Naber C., Neuerburg C., Mazaheri B., Neuerburg C., Athanasia S., Giannitsioti E., Mylona E., Paniara O., Papanicolaou K., Pyros J., Skoutelis A., Sharma G., Francis J., Nair L., Thomas V., Venugopal K., Hannan M., Hurley J., Gilon D., Israel S., Korem M., Strahilevitz J., Rubinstein E., Strahilevitz J., Tripodi M.F., Casillo R., Cuccurullo S., Dialetto G., Durante-Mangoni E., Irene M., Ragone E., Utili R., Cecchi E., De Rosa F., Forno D., Imazio M., Trinchero R., Tebini A., Grossi P., Lattanzio M., Toniolo A., Goglio A., Raglio A., Ravasio V., Rizzi M., Suter F., Carosi G., Magri S., Signorini L., Baban T., Kanafani Z., Kanj S.S., Sfeir J., Yasmine M., Abidin I., Tamin S.S., Martínez E.R., Nieto G.I.S., van der Meer J.T.M., Chambers S., Holland D., Morris A., Raymond N., Read K., Murdoch D.R., Dragulescu S., Ionac A., Mornos C., Butkevich O.M., Chipigina N., Kirill O., Vadim K., Vinogradova T., Edathodu J., Halim M., Lum L.-N., Tan R.-S., Lejko-Zupanc T., Logar M., Mueller-Premru M., Commerford P., Commerford A., Deetlefs E., Hansa C., Ntsekhe M., Almela M., Armero Y., Azqueta M., Castañeda X., Cervera C., Rio A., Falces C., Garcia-de-la-Maria C., Fita G., Gatell J.M., Marco F., Mestres C.A., Miró J.M., Moreno A., Ninot S., Paré C., Pericas J., Ramirez J., Rovira I., Sitges M., Anguera I., Font B., Guma J.R., Bermejo J., Bouza E., Fernández M.A.G., Gonzalez-Ramallo V., Marín M., Muñoz P., Pedromingo M., Roda J., Rodríguez-Créixems M., Solis J., Almirante B., Fernandez-Hidalgo N., Tornos P., de Alarcón A., Parra R., Alestig E., Johansson M., Olaison L., Snygg-Martin U., Pachirat O., Pachirat P., Pussadhamma B., Senthong V., Casey A., Elliott T., Lambert P., Watkin R., Eyton C., Klein J.L., Bradley S., Kauffman C., Bedimo R., Chu V.H., Corey G.R., Crowley A.L., Douglas P., Drew L., Fowler V.G., Holland T., Lalani T., Mudrick D., Samad Z., Sexton D., Stryjewski M., Wang A., Woods C.W., Lerakis S., Cantey R., Steed L., Wray D., Dickerman S.A., Bonilla H., DiPersio J., Salstrom S.-J., Baddley J., Patel M., Peterson G., Stancoven A., Afonso L., Kulman T., Levine D., Rybak M., Cabell C.H., Baloch K., Chu V.H., Corey G.R., Dixon C.C., Fowler Jr. V.G., Harding T., Jones-Richmond M., Pappas P., Park L.P., Redick T., Stafford J., Anstrom K., Athan E., Bayer A.S., Cabell C.H., Chu V.H., Hoen B., Karchmer A.W., Murdoch D.R., Sexton D.J., Wang A., Bayer A.S., Cabell C.H., Chu V., Durack D.T., Eykyn S., Hoen B., Moreillon P., Olaison L., Raoult D., Rubinstein E. (2013). HACEK Infective Endocarditis: Characteristics and Outcomes from a Large, Multi-National Cohort. PLoS ONE 8 (5) : e63181. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0063181 | Rights: | Attribution 4.0 International | Abstract: | The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics and outcomes of patients with HACEK endocarditis (HE) in a large multi-national cohort. Patients hospitalized with definite or possible infective endocarditis by the International Collaboration on Endocarditis Prospective Cohort Study in 64 hospitals from 28 countries were included and characteristics of HE patients compared with IE due to other pathogens. Of 5591 patients enrolled, 77 (1.4%) had HE. HE was associated with a younger age (47 vs. 61 years; p<0.001), a higher prevalence of immunologic/vascular manifestations (32% vs. 20%; p<0.008) and stroke (25% vs. 17% p = 0.05) but a lower prevalence of congestive heart failure (15% vs. 30%; p = 0.004), death in-hospital (4% vs. 18%; p = 0.001) or after 1 year follow-up (6% vs. 20%; p = 0.01) than IE due to other pathogens (n = 5514). On multivariable analysis, stroke was associated with mitral valve vegetations (OR 3.60; CI 1.34-9.65; p<0.01) and younger age (OR 0.62; CI 0.49-0.90; p<0.01). The overall outcome of HE was excellent with the in-hospital mortality (4%) significantly better than for non-HE (18%; p<0.001). Prosthetic valve endocarditis was more common in HE (35%) than non-HE (24%). The outcome of prosthetic valve and native valve HE was excellent whether treated medically or with surgery. Current treatment is very successful for the management of both native valve prosthetic valve HE but further studies are needed to determine why HE has a predilection for younger people and to cause stroke. The small number of patients and observational design limit inferences on treatment strategies. Self selection of study sites limits epidemiological inferences. © 2013 Chambers et al. | Source Title: | PLoS ONE | URI: | https://scholarbank.nus.edu.sg/handle/10635/161316 | ISSN: | 19326203 | DOI: | 10.1371/journal.pone.0063181 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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