Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0063181
Title: HACEK Infective Endocarditis: Characteristics and Outcomes from a Large, Multi-National Cohort
Authors: Chambers S.T.
Murdoch D.
Morris A.
Holland D.
Pappas P.
Almela M.
Fernández-Hidalgo N.
Almirante B.
Bouza E.
Forno D.
Rio A.
Hannan M.M.
Harkness J.
Kanafani Z.A.
Lalani T.
Lang S.
Raymond N.
Read K.
Vinogradova T.
Woods C.W.
Wray D.
Corey G.R.
Chu V.H.
Clara L.
Sanchez M.
Nacinovich F.
Oses P.F.
Ronderos R.
Sucari A.
Thierer J.
Casabé J.
Cortes C.
Altclas J.
Silvia Kogan S.
Spelman D.
Athan E.
Harris O.
Kennedy K.
Tan R.
Gordon D.
Papanicolas L.
Eisen D.
Grigg L.
Street A.
Korman T.
Kotsanas D.
Dever R.
Jones P.
Konecny P.
Lawrence R.
Rees D.
Ryan S.
Feneley M.P.
Harkness J.
Jones P.
Ryan S.
Jones P.
Ryan S.
Jones P.
Post J.
Reinbott P.
Ryan S.
Gattringer R.
Wiesbauer F.
Andrade A.R.
de Brito A.C.P.
Guimarães A.C.
Grinberg M.
Mansur A.J.
Siciliano R.F.
Strabelli T.M.V.
Vieira M.L.C.
de Medeiros Tranchesi R.A.
Paiva M.G.
Fortes C.Q.
de Oliveira Ramos A.
Ferraiuoli G.
Golebiovski W.
Lamas C.
Santos M.
Weksler C.
Karlowsky J.A.
Keynan Y.
Morris A.M.
Rubinstein E.
Jones S.B.
Garcia P.
Cereceda M.
Fica A.
Mella R.M.
Barsic B.
Bukovski S.
Krajinovic V.
Pangercic A.
Rudez I.
Vincelj J.
Freiberger T.
Pol J.
Zaloudikova B.
Ashour Z.
Kholy A.E.
Mishaal M.
Rizk H.
Aissa N.
Alauzet C.
Alla F.
Campagnac C.
Doco-Lecompte T.
Selton-Suty C.
Casalta J.-P.
Fournier P.-E.
Habib G.
Raoult D.
Thuny F.
Delahaye F.
Delahaye A.
Vandenesch F.
Donal E.
Donnio P.Y.
Michelet C.
Revest M.
Tattevin P.
Violette J.
Chevalier F.
Jeu A.
Rusinaru D.M.D.
Sorel C.
Tribouilloy C.
Bernard Y.
Chirouze C.
Hoen B.
Leroy J.
Plesiat P.
Naber C.
Neuerburg C.
Mazaheri B.
Neuerburg C.
Athanasia S.
Giannitsioti E.
Mylona E.
Paniara O.
Papanicolaou K.
Pyros J.
Skoutelis A.
Sharma G.
Francis J.
Nair L.
Thomas V.
Venugopal K.
Hannan M.
Hurley J.
Gilon D.
Israel S.
Korem M.
Strahilevitz J.
Rubinstein E.
Strahilevitz J.
Tripodi M.F.
Casillo R.
Cuccurullo S.
Dialetto G.
Durante-Mangoni E.
Irene M.
Ragone E.
Utili R.
Cecchi E.
De Rosa F.
Forno D.
Imazio M.
Trinchero R.
Tebini A.
Grossi P.
Lattanzio M.
Toniolo A.
Goglio A.
Raglio A.
Ravasio V.
Rizzi M.
Suter F.
Carosi G.
Magri S.
Signorini L.
Baban T.
Kanafani Z.
Kanj S.S.
Sfeir J.
Yasmine M.
Abidin I.
Tamin S.S.
Martínez E.R.
Nieto G.I.S.
van der Meer J.T.M.
Chambers S.
Holland D.
Morris A.
Raymond N.
Read K.
Murdoch D.R.
Dragulescu S.
Ionac A.
Mornos C.
Butkevich O.M.
Chipigina N.
Kirill O.
Vadim K.
Vinogradova T.
Edathodu J.
Halim M.
Lum L.-N.
Tan R.-S. 
Lejko-Zupanc T.
Logar M.
Mueller-Premru M.
Commerford P.
Commerford A.
Deetlefs E.
Hansa C.
Ntsekhe M.
Almela M.
Armero Y.
Azqueta M.
Castañeda X.
Cervera C.
Rio A.
Falces C.
Garcia-de-la-Maria C.
Fita G.
Gatell J.M.
Marco F.
Mestres C.A.
Miró J.M.
Moreno A.
Ninot S.
Paré C.
Pericas J.
Ramirez J.
Rovira I.
Sitges M.
Anguera I.
Font B.
Guma J.R.
Bermejo J.
Bouza E.
Fernández M.A.G.
Gonzalez-Ramallo V.
Marín M.
Muñoz P.
Pedromingo M.
Roda J.
Rodríguez-Créixems M.
Solis J.
Almirante B.
Fernandez-Hidalgo N.
Tornos P.
de Alarcón A.
Parra R.
Alestig E.
Johansson M.
Olaison L.
Snygg-Martin U.
Pachirat O.
Pachirat P.
Pussadhamma B.
Senthong V.
Casey A.
Elliott T.
Lambert P.
Watkin R.
Eyton C.
Klein J.L.
Bradley S.
Kauffman C.
Bedimo R.
Chu V.H.
Corey G.R.
Crowley A.L.
Douglas P.
Drew L.
Fowler V.G.
Holland T.
Lalani T.
Mudrick D.
Samad Z.
Sexton D.
Stryjewski M.
Wang A.
Woods C.W.
Lerakis S.
Cantey R.
Steed L.
Wray D.
Dickerman S.A.
Bonilla H.
DiPersio J.
Salstrom S.-J.
Baddley J.
Patel M.
Peterson G.
Stancoven A.
Afonso L.
Kulman T.
Levine D.
Rybak M.
Cabell C.H.
Baloch K.
Chu V.H.
Corey G.R.
Dixon C.C.
Fowler Jr. V.G.
Harding T.
Jones-Richmond M.
Pappas P.
Park L.P.
Redick T.
Stafford J.
Anstrom K.
Athan E.
Bayer A.S.
Cabell C.H.
Chu V.H.
Hoen B.
Karchmer A.W.
Murdoch D.R.
Sexton D.J.
Wang A.
Bayer A.S.
Cabell C.H.
Chu V.
Durack D.T.
Eykyn S.
Hoen B.
Moreillon P.
Olaison L.
Raoult D.
Rubinstein E.
Keywords: aminoglycoside
ampicillin
cefalotin
cefazolin
ceftriaxone
gentamicin
penicillin G
penicillinase
adult
Africa
age
Aggregatibacter
antimicrobial therapy
aorta valve prosthesis
article
Asia
Australia
bacterial endocarditis
Cardiobacterium hominis
cerebrovascular accident
congenital heart disease
congestive heart failure
controlled study
diabetes mellitus
disease association
Eikenella corrodens
endocarditis
Europe
female
follow up
Haemophilus
heart murmur
heart surgery
heart valve regurgitation
hospitalization
human
immunology
Kingella
major clinical study
male
Middle East
mitral valve disease
mortality
native valve endocarditis
New Zealand
North America
outcome assessment
prevalence
prosthetic valve endocarditis
South America
Aggregatibacter
Cardiobacterium
cohort analysis
Eikenella corrodens
Endocarditis, Bacterial
Haemophilus
Kingella
microbiology
nonparametric test
pathophysiology
risk
treatment outcome
Age Factors
Aggregatibacter
Cardiobacterium
Cohort Studies
Eikenella corrodens
Endocarditis, Bacterial
Haemophilus
Humans
Kingella
Odds Ratio
Prevalence
Statistics, Nonparametric
Treatment Outcome
Issue Date: 2013
Citation: Chambers S.T., Murdoch D., Morris A., Holland D., Pappas P., Almela M., Fernández-Hidalgo N., Almirante B., Bouza E., Forno D., Rio A., Hannan M.M., Harkness J., Kanafani Z.A., Lalani T., Lang S., Raymond N., Read K., Vinogradova T., Woods C.W., Wray D., Corey G.R., Chu V.H., Clara L., Sanchez M., Nacinovich F., Oses P.F., Ronderos R., Sucari A., Thierer J., Casabé J., Cortes C., Altclas J., Silvia Kogan S., Spelman D., Athan E., Harris O., Kennedy K., Tan R., Gordon D., Papanicolas L., Eisen D., Grigg L., Street A., Korman T., Kotsanas D., Dever R., Jones P., Konecny P., Lawrence R., Rees D., Ryan S., Feneley M.P., Harkness J., Jones P., Ryan S., Jones P., Ryan S., Jones P., Post J., Reinbott P., Ryan S., Gattringer R., Wiesbauer F., Andrade A.R., de Brito A.C.P., Guimarães A.C., Grinberg M., Mansur A.J., Siciliano R.F., Strabelli T.M.V., Vieira M.L.C., de Medeiros Tranchesi R.A., Paiva M.G., Fortes C.Q., de Oliveira Ramos A., Ferraiuoli G., Golebiovski W., Lamas C., Santos M., Weksler C., Karlowsky J.A., Keynan Y., Morris A.M., Rubinstein E., Jones S.B., Garcia P., Cereceda M., Fica A., Mella R.M., Barsic B., Bukovski S., Krajinovic V., Pangercic A., Rudez I., Vincelj J., Freiberger T., Pol J., Zaloudikova B., Ashour Z., Kholy A.E., Mishaal M., Rizk H., Aissa N., Alauzet C., Alla F., Campagnac C., Doco-Lecompte T., Selton-Suty C., Casalta J.-P., Fournier P.-E., Habib G., Raoult D., Thuny F., Delahaye F., Delahaye A., Vandenesch F., Donal E., Donnio P.Y., Michelet C., Revest M., Tattevin P., Violette J., Chevalier F., Jeu A., Rusinaru D.M.D., Sorel C., Tribouilloy C., Bernard Y., Chirouze C., Hoen B., Leroy J., Plesiat P., Naber C., Neuerburg C., Mazaheri B., Neuerburg C., Athanasia S., Giannitsioti E., Mylona E., Paniara O., Papanicolaou K., Pyros J., Skoutelis A., Sharma G., Francis J., Nair L., Thomas V., Venugopal K., Hannan M., Hurley J., Gilon D., Israel S., Korem M., Strahilevitz J., Rubinstein E., Strahilevitz J., Tripodi M.F., Casillo R., Cuccurullo S., Dialetto G., Durante-Mangoni E., Irene M., Ragone E., Utili R., Cecchi E., De Rosa F., Forno D., Imazio M., Trinchero R., Tebini A., Grossi P., Lattanzio M., Toniolo A., Goglio A., Raglio A., Ravasio V., Rizzi M., Suter F., Carosi G., Magri S., Signorini L., Baban T., Kanafani Z., Kanj S.S., Sfeir J., Yasmine M., Abidin I., Tamin S.S., Martínez E.R., Nieto G.I.S., van der Meer J.T.M., Chambers S., Holland D., Morris A., Raymond N., Read K., Murdoch D.R., Dragulescu S., Ionac A., Mornos C., Butkevich O.M., Chipigina N., Kirill O., Vadim K., Vinogradova T., Edathodu J., Halim M., Lum L.-N., Tan R.-S., Lejko-Zupanc T., Logar M., Mueller-Premru M., Commerford P., Commerford A., Deetlefs E., Hansa C., Ntsekhe M., Almela M., Armero Y., Azqueta M., Castañeda X., Cervera C., Rio A., Falces C., Garcia-de-la-Maria C., Fita G., Gatell J.M., Marco F., Mestres C.A., Miró J.M., Moreno A., Ninot S., Paré C., Pericas J., Ramirez J., Rovira I., Sitges M., Anguera I., Font B., Guma J.R., Bermejo J., Bouza E., Fernández M.A.G., Gonzalez-Ramallo V., Marín M., Muñoz P., Pedromingo M., Roda J., Rodríguez-Créixems M., Solis J., Almirante B., Fernandez-Hidalgo N., Tornos P., de Alarcón A., Parra R., Alestig E., Johansson M., Olaison L., Snygg-Martin U., Pachirat O., Pachirat P., Pussadhamma B., Senthong V., Casey A., Elliott T., Lambert P., Watkin R., Eyton C., Klein J.L., Bradley S., Kauffman C., Bedimo R., Chu V.H., Corey G.R., Crowley A.L., Douglas P., Drew L., Fowler V.G., Holland T., Lalani T., Mudrick D., Samad Z., Sexton D., Stryjewski M., Wang A., Woods C.W., Lerakis S., Cantey R., Steed L., Wray D., Dickerman S.A., Bonilla H., DiPersio J., Salstrom S.-J., Baddley J., Patel M., Peterson G., Stancoven A., Afonso L., Kulman T., Levine D., Rybak M., Cabell C.H., Baloch K., Chu V.H., Corey G.R., Dixon C.C., Fowler Jr. V.G., Harding T., Jones-Richmond M., Pappas P., Park L.P., Redick T., Stafford J., Anstrom K., Athan E., Bayer A.S., Cabell C.H., Chu V.H., Hoen B., Karchmer A.W., Murdoch D.R., Sexton D.J., Wang A., Bayer A.S., Cabell C.H., Chu V., Durack D.T., Eykyn S., Hoen B., Moreillon P., Olaison L., Raoult D., Rubinstein E. (2013). HACEK Infective Endocarditis: Characteristics and Outcomes from a Large, Multi-National Cohort. PLoS ONE 8 (5) : e63181. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0063181
Abstract: The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics and outcomes of patients with HACEK endocarditis (HE) in a large multi-national cohort. Patients hospitalized with definite or possible infective endocarditis by the International Collaboration on Endocarditis Prospective Cohort Study in 64 hospitals from 28 countries were included and characteristics of HE patients compared with IE due to other pathogens. Of 5591 patients enrolled, 77 (1.4%) had HE. HE was associated with a younger age (47 vs. 61 years; p<0.001), a higher prevalence of immunologic/vascular manifestations (32% vs. 20%; p<0.008) and stroke (25% vs. 17% p = 0.05) but a lower prevalence of congestive heart failure (15% vs. 30%; p = 0.004), death in-hospital (4% vs. 18%; p = 0.001) or after 1 year follow-up (6% vs. 20%; p = 0.01) than IE due to other pathogens (n = 5514). On multivariable analysis, stroke was associated with mitral valve vegetations (OR 3.60; CI 1.34-9.65; p<0.01) and younger age (OR 0.62; CI 0.49-0.90; p<0.01). The overall outcome of HE was excellent with the in-hospital mortality (4%) significantly better than for non-HE (18%; p<0.001). Prosthetic valve endocarditis was more common in HE (35%) than non-HE (24%). The outcome of prosthetic valve and native valve HE was excellent whether treated medically or with surgery. Current treatment is very successful for the management of both native valve prosthetic valve HE but further studies are needed to determine why HE has a predilection for younger people and to cause stroke. The small number of patients and observational design limit inferences on treatment strategies. Self selection of study sites limits epidemiological inferences. © 2013 Chambers et al.
Source Title: PLoS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/161316
ISSN: 19326203
DOI: 10.1371/journal.pone.0063181
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