Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0196465
Title: A prospective evaluation of serum kynurenine metabolites and risk of pancreatic cancer
Authors: Huang J.Y.
Butler L.M.
Midttun Ø.
Ulvik A.
Wang R.
Jin A.
Gao Y.-T.
Ueland P.M.
Koh W.-P. 
Yuan J.-M.
Keywords: 3 hydroxyanthranilic acid
3 hydroxykynurenine
kynurenine
neopterin
pyridoxal 5 phosphate
tryptophan
3 hydroxyanthranilic acid
3-hydroxykynurenine
biological marker
kynurenine
pyridoxal 5 phosphate
pyridoxine
adult
aged
amino acid blood level
Article
cancer risk
case control study
clinical evaluation
cohort analysis
confidence interval
controlled study
female
human
in vivo study
major clinical study
male
odds ratio
pancreas cancer
prospective study
vitamin blood level
analogs and derivatives
blood
China
metabolism
middle aged
pancreas tumor
risk factor
3-Hydroxyanthranilic Acid
Biomarkers
Case-Control Studies
China
Female
Humans
Kynurenine
Male
Middle Aged
Odds Ratio
Pancreatic Neoplasms
Prospective Studies
Pyridoxal Phosphate
Risk Factors
Vitamin B 6
Issue Date: 2018
Citation: Huang J.Y., Butler L.M., Midttun Ø., Ulvik A., Wang R., Jin A., Gao Y.-T., Ueland P.M., Koh W.-P., Yuan J.-M. (2018). A prospective evaluation of serum kynurenine metabolites and risk of pancreatic cancer. PLoS ONE 13 (5) : e0196465. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0196465
Rights: Attribution 4.0 International
Abstract: Background Serum pyridoxal 5’-phosphate (PLP), the active form of vitamin B6, is associated with reduced risk of pancreatic cancer. Data on functional measures of vitamin B6 status and risk of pancreatic cancer is lacking. Methods A nested case-control study involving 187 incident cases of pancreatic cancer and 362 individually matched controls were conducted within two prospective cohorts to evaluate the associations between kynurenine metabolites in pre-diagnostic serum samples and risk of pancreatic cancer. Results Higher serum concentrations of 3-hydroxyanthranilic acid (HAA) and the HAA:3-hydroxyky-nurenine (HK) ratio (a measure for in vivo functional status of PLP) were significantly associated with reduced risk of pancreatic cancer. Compared with the lowest tertile, odds ratios (95% confidence intervals) of pancreatic cancer for the highest tertile was 0.62 (0.39, 1.01) for HAA, and 0.59 (0.35–0.98) for the HAA:HK ratio, after adjustment for potential confounders and serum PLP (both Ps for trend<0.05). The kynurenine:tryptophan ratio or neopterin was not significantly associated with pancreatic cancer risk. Conclusions The inverse association between HAA or the HAA:HK ratio and risk of pancreatic cancer supports the notion that functional status of PLP may be a more important measure than circulating PLP alone for the development of pancreatic cancer. © 2018 Huang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Source Title: PLoS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/161230
ISSN: 19326203
DOI: 10.1371/journal.pone.0196465
Rights: Attribution 4.0 International
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