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https://doi.org/10.1002/adma.201800766
Title: | Bright Aggregation-Induced-Emission Dots for Targeted Synergetic NIR-II Fluorescence and NIR-I Photoacoustic Imaging of Orthotopic Brain Tumors | Authors: | SHENG, ZONGHAI GUO, BING HU, DEHONG XU, SHIDANG WU, WENBO LIEW, WENG HENG YAO, KUI JIANG, JINGYING LIU, CHENGBO ZHENG, HAIRONG LIU, BIN |
Keywords: | Science & Technology Physical Sciences Technology Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Chemistry Science & Technology - Other Topics Materials Science Physics aggregation-induced emission brain tumors nanoparticles NIR-II fluorescence imaging photoacoustic imaging NEAR-INFRARED WINDOW ORGANIC NANOPARTICLES MODALITY MRI CANCER THERAPY FLUOROPHORE DIAGNOSIS DELIVERY SURGERY BARRIER |
Issue Date: | 19-Jul-2018 | Publisher: | WILEY-V C H VERLAG GMBH | Citation: | SHENG, ZONGHAI, GUO, BING, HU, DEHONG, XU, SHIDANG, WU, WENBO, LIEW, WENG HENG, YAO, KUI, JIANG, JINGYING, LIU, CHENGBO, ZHENG, HAIRONG, LIU, BIN (2018-07-19). Bright Aggregation-Induced-Emission Dots for Targeted Synergetic NIR-II Fluorescence and NIR-I Photoacoustic Imaging of Orthotopic Brain Tumors. ADVANCED MATERIALS 30 (29). ScholarBank@NUS Repository. https://doi.org/10.1002/adma.201800766 | Abstract: | © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Precise diagnostics are of significant importance to the optimal treatment outcomes of patients bearing brain tumors. NIR-II fluorescence imaging holds great promise for brain-tumor diagnostics with deep penetration and high sensitivity. This requires the development of organic NIR-II fluorescent agents with high quantum yield (QY), which is difficult to achieve. Herein, the design and synthesis of a new NIR-II fluorescent molecule with aggregation-induced-emission (AIE) characteristics is reported for orthotopic brain-tumor imaging. Encapsulation of the molecule in a polymer matrix yields AIE dots showing a very high QY of 6.2% with a large absorptivity of 10.2 L g−1 cm−1 at 740 nm and an emission maximum near 1000 nm. Further decoration of the AIE dots with c-RGD yields targeted AIE dots, which afford specific and selective tumor uptake, with a high signal/background ratio of 4.4 and resolution up to 38 µm. The large NIR absorptivity of the AIE dots facilitates NIR-I photoacoustic imaging with intrinsically deeper penetration than NIR-II fluorescence imaging and, more importantly, precise tumor-depth detection through intact scalp and skull. This research demonstrates the promise of NIR-II AIE molecules and their dots in dual NIR-II fluorescence and NIR-I photoacoustic imaging for precise brain cancer diagnostics. | Source Title: | ADVANCED MATERIALS | URI: | https://scholarbank.nus.edu.sg/handle/10635/155306 | ISSN: | 09359648 15214095 |
DOI: | 10.1002/adma.201800766 |
Appears in Collections: | Staff Publications Elements |
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2018-AM-AIE_NIRII May 28, 2018.pdf | Published version | 2.93 MB | Adobe PDF | CLOSED | None |
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