Please use this identifier to cite or link to this item: https://doi.org/10.1093/database/bau015
Title: NCG 4.0: The network of cancer genes in the era of massive mutational screenings of cancer genomes
Authors: An, O 
Pendino, V
D'Antonio, M
Ratti, E
Gentilini, M
Ciccarelli, FD
Keywords: Databases, Genetic
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Gene Regulatory Networks
Genetic Association Studies
Genome, Human
Humans
Internet
MicroRNAs
Mutation
Neoplasms
Search Engine
Software
Issue Date: 1-Jan-2014
Publisher: Oxford University Press (OUP)
Citation: An, O, Pendino, V, D'Antonio, M, Ratti, E, Gentilini, M, Ciccarelli, FD (2014-01-01). NCG 4.0: The network of cancer genes in the era of massive mutational screenings of cancer genomes. Database 2014 : bau015-. ScholarBank@NUS Repository. https://doi.org/10.1093/database/bau015
Abstract: © The Author(s) 2014. NCG 4.0 is the latest update of the Network of Cancer Genes, a web-based repository of systems-level properties of cancer genes. In its current version, the database collects information on 537 known (i.e. experimentally supported) and 1463 candidate (i.e. inferred using statistical methods) cancer genes. Candidate cancer genes derive from the manual revision of 67 original publications describing the mutational screening of 3460 human exomes and genomes in 23 different cancer types. For all 2000 cancer genes, duplicability, evolutionary origin, expression, functional annotation, interaction network with other human proteins and with microRNAs are reported. In addition to providing a substantial update of cancer-related information, NCG 4.0 also introduces two new features. The first is the annotation of possible false-positive cancer drivers, defined as candidate cancer genes inferred from large-scale screenings whose association with cancer is likely to be spurious. The second is the description of the systems-level properties of 64 human microRNAs that are causally involved in cancer progression (oncomiRs). Owing to the manual revision of all information, NCG 4.0 constitutes a complete and reliable resource on human coding and non-coding genes whose deregulation drives cancer onset and/or progression. NCG 4.0 can also be downloaded as a free application for Android smart phones.
Source Title: Database
URI: https://scholarbank.nus.edu.sg/handle/10635/155279
ISSN: 1758-0463
1758-0463
DOI: 10.1093/database/bau015
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