Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.eplepsyres.2019.03.006
Title: | PROLIFERATION OF NG2 CELLS IN THE EPILEPTIC HIPPOCAMPUS | Authors: | Wu, XL Zhou, JS Wang, LH Liu, JX Hu, HB Zhang, XT Li, YJ Tang, FR |
Keywords: | Epilepsy Glia cell Hippocampus NG2 |
Issue Date: | 1-May-2019 | Publisher: | Elsevier BV | Citation: | Wu, XL, Zhou, JS, Wang, LH, Liu, JX, Hu, HB, Zhang, XT, Li, YJ, Tang, FR (2019-05-01). PROLIFERATION OF NG2 CELLS IN THE EPILEPTIC HIPPOCAMPUS. Epilepsy Research 152 : 67-72. ScholarBank@NUS Repository. https://doi.org/10.1016/j.eplepsyres.2019.03.006 | Abstract: | © 2019 Elsevier B.V. NG2 cells are oligodendrocyte progenitor cells, and have been shown to receive synaptic input from pyramidal neurons to generate action potentials. Whether any change of these cells occurs after status epilepticus (SE) and subsequent temporal lobe epilepsy remains unknown. In the present study, the expression of NG2 was investigated in the mouse hippocampus after pilocarpine-induced status epilepticus (PISE). We showed that reactive NG2 cells were significantly increased from 1 day to 2 months after PISE. Double immunofluorescence indicated that few NG2 cells differentiated into neurons and astrocytes after PISE, whereas the number of NG2 cells was increased significantly in the stratum lucidum of CA3 area from 1 day onwards after PISE. Our results suggest that the significantly increased reactive NG2 cells from acute to chronic stage after PISE may be involved in epileptogenesis. | Source Title: | Epilepsy Research | URI: | https://scholarbank.nus.edu.sg/handle/10635/155230 | ISSN: | 0920-1211 1872-6844 |
DOI: | 10.1016/j.eplepsyres.2019.03.006 |
Appears in Collections: | Staff Publications Elements |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
Wu XL.pdf | Published version | 5.68 MB | Adobe PDF | OPEN | None | View/Download |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.