Please use this identifier to cite or link to this item: https://doi.org/10.1007/s12185-018-2518-z
Title: Oncogenic transcriptional program driven by TAL1 in T-cell acute lymphoblastic leukemia
Authors: Tan, Tze King 
Zhang, Chujing
Sanda, Takaomi 
Keywords: Science & Technology
Life Sciences & Biomedicine
Hematology
TAL1
T-cell acute lymphoblastic leukemia
Transcription factor
GENOME-WIDE ANALYSIS
LONG NONCODING RNAS
HEMATOPOIETIC STEM
GENE-EXPRESSION
CHROMOSOMAL TRANSLOCATION
THYMOCYTE DEVELOPMENT
PATHWAY ACTIVATION
DIRECT TARGET
CYCLIN D3
C-MYC
Issue Date: 1-Jan-2019
Publisher: SPRINGER JAPAN KK
Citation: Tan, Tze King, Zhang, Chujing, Sanda, Takaomi (2019-01-01). Oncogenic transcriptional program driven by TAL1 in T-cell acute lymphoblastic leukemia. INTERNATIONAL JOURNAL OF HEMATOLOGY 109 (1) : 5-17. ScholarBank@NUS Repository. https://doi.org/10.1007/s12185-018-2518-z
Abstract: © 2018, The Japanese Society of Hematology. TAL1/SCL is a prime example of an oncogenic transcription factor that is abnormally expressed in acute leukemia due to the replacement of regulator elements. This gene has also been recognized as an essential regulator of hematopoiesis. TAL1 expression is strictly regulated in a lineage- and stage-specific manner. Such precise control is crucial for the switching of the transcriptional program. The misexpression of TAL1 in immature thymocytes leads to a widespread series of orchestrated downstream events that affect several different cellular machineries, resulting in a lethal consequence, namely T-cell acute lymphoblastic leukemia (T-ALL). In this article, we will discuss the transcriptional regulatory network and downstream target genes, including protein-coding genes and non-coding RNAs, controlled by TAL1 in normal hematopoiesis and T-cell leukemogenesis.
Source Title: INTERNATIONAL JOURNAL OF HEMATOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/155213
ISSN: 0925-5710
1865-3774
DOI: 10.1007/s12185-018-2518-z
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