Please use this identifier to cite or link to this item: https://doi.org/10.1177/2472630319846877
Title: ADVANCES IN TECHNOLOGIES FOR PURIFICATION AND ENRICHMENT OF EXTRACELLULAR VESICLES.
Authors: Zhang, Pan
Yeo, Joo Chuan 
Lim, Chwee Teck 
Keywords: Extracellular vesicles
enrichment
isolation
microfluidics
microtechnology
purification
Issue Date: 14-May-2019
Citation: Zhang, Pan, Yeo, Joo Chuan, Lim, Chwee Teck (2019-05-14). ADVANCES IN TECHNOLOGIES FOR PURIFICATION AND ENRICHMENT OF EXTRACELLULAR VESICLES.. SLAS Technol : 2472630319846877-. ScholarBank@NUS Repository. https://doi.org/10.1177/2472630319846877
Abstract: Extracellular vesicles (EVs) are lipid bilayer-bound vesicles secreted by cells. Subtypes of EVs such as microvesicles and exosomes are further categorized mainly by their different biogenesis mechanisms. EVs have been revealed to play an important role in disease diagnosis and intercellular communication. Despite the wide interest in EVs, the technologies for the purification and enrichment of EVs are still in their infancy. The isolation of EVs, especially exosomes, is inherently challenging due to their small size and heterogeneity. In this review, we mainly introduce the advances of techniques in isolating microvesicles and exosomes according to their approaches. Also, we discuss the limitations of currently reported technologies in terms of their specificity and efficiency, and provide our thoughts about future developments of EV purification and enrichment technology.
Source Title: SLAS Technol
URI: https://scholarbank.nus.edu.sg/handle/10635/155197
ISSN: 2472-6303
2472-6311
DOI: 10.1177/2472630319846877
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