Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-019-42190-1
Title: Changes in the Canine Plasma Lipidome after Short- and Long-Term Excess Glucocorticoid Exposure
Authors: Sieber-Ruckstuhl, Nadja S
BO JOHANNES BURLA 
Spoerel, Susanne
Schmid, Florence
Venzin, Claudio
AMAURY CAZENAVE GASSIOT 
BENDT,ANNE KATHRIN 
Torta, Federico
MARKUS R WENK 
Boretti, Felicitas S
Keywords: Adrenal gland diseases
Dyslipidaemias
Lipidomics
Issue Date: 12-Apr-2019
Citation: Sieber-Ruckstuhl, Nadja S, BO JOHANNES BURLA, Spoerel, Susanne, Schmid, Florence, Venzin, Claudio, AMAURY CAZENAVE GASSIOT, BENDT,ANNE KATHRIN, Torta, Federico, MARKUS R WENK, Boretti, Felicitas S (2019-04-12). Changes in the Canine Plasma Lipidome after Short- and Long-Term Excess Glucocorticoid Exposure. Scientific Reports 9 (1) : 6015. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-019-42190-1
Abstract: Glucocorticoids (GCs) are critical regulators of metabolic control in mammals and their aberrant function has been linked to several pathologies. GCs are widely used in human and veterinary clinical practice as potent anti-inflammatory and immune suppressive agents. Dyslipidaemia is a frequently observed consequence of GC treatment, typified by increased lipolysis, lipid mobilization, liponeogenesis, and adipogenesis. Dogs with excess GC show hyperlipidaemia, hypertension, and a higher risk of developing type 2 diabetes mellitus, but the risk of developing atherosclerotic lesions is low as compared to humans. This study aimed to examine alterations in the canine plasma lipidome in a model of experimentally induced short-term and long-term GC excess. Both treatments led to significant plasma lipidome alterations, which were more pronounced after long-term excess steroid exposure. In particular, monohexosylceramides, phosphatidylinositols, ether phosphatidylcholines, acyl phosphatidylcholines, triacylglycerols and sphingosine 1-phosphates showed significant changes. The present study highlights the hitherto unknown effects of GCs on lipid metabolism, which will be important in the further elucidation of the role and function of GCs as drugs and in metabolic and cardiovascular diseases.
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/154070
ISSN: 2045-2322
DOI: 10.1038/s41598-019-42190-1
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