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Title: High-risk human papillomaviral oncogenes E6 and E7 target key cellular pathways to achieve oncogenesis
Authors: Yeo-Teh N.S.L. 
Ito Y. 
Jha S. 
Keywords: Cervical cancer; E6; E7; HPV; Human papillomavirus; Viral oncogenes; Viral-induced cancers
Issue Date: 2018
Publisher: MDPI AG
Citation: Yeo-Teh N.S.L., Ito Y., Jha S. (2018). High-risk human papillomaviral oncogenes E6 and E7 target key cellular pathways to achieve oncogenesis. International Journal of Molecular Sciences 19 (6) : 1-27. ScholarBank@NUS Repository.
Abstract: Infection with high-risk human papillomavirus (HPV) has been linked to several human cancers, the most prominent of which is cervical cancer. The integration of the viral genome into the host genome is one of the manners in which the viral oncogenes E6 and E7 achieve persistent expression. The most well-studied cellular targets of the viral oncogenes E6 and E7 are p53 and pRb, respectively. However, recent research has demonstrated the ability of these two viral factors to target many more cellular factors, including proteins which regulate epigenetic marks and splicing changes in the cell. These have the ability to exert a global change, which eventually culminates to uncontrolled proliferation and carcinogenesis. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: International Journal of Molecular Sciences
ISSN: 16616596
DOI: 10.3390/ijms19061706
Appears in Collections:Staff Publications

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