Please use this identifier to cite or link to this item: https://doi.org/10.1093/cercor/bhy018
Title: Rab23 regulates radial migration of projection neurons via N-cadherin
Authors: Hor C.H.H. 
Goh E.L.K. 
Keywords: Corticogenesis
ERK1/2
GTPase
N-cadherin
PDGFR?
Rab23
Radial migration
Issue Date: 2018
Publisher: Oxford University Press
Citation: Hor C.H.H., Goh E.L.K. (2018). Rab23 regulates radial migration of projection neurons via N-cadherin. Cerebral Cortex 28 (4) : 1516-1531. ScholarBank@NUS Repository. https://doi.org/10.1093/cercor/bhy018
Abstract: Radial migration of cortical projection neurons is a prerequisite for shaping a distinct multilayered cerebral cortex during mammalian corticogenesis. Members of Rab GTPases family were reported to regulate radial migration. Here, in vivo conditional knockout or in utero knockdown (KD) of Rab23 in mice neocortex causes aberrant polarity and halted migration of cortical projection neurons. Further investigation of the underlying mechanism reveals down-regulation of N-cadherin in the Rab23-deficient neurons, which is a cell adhesion protein previously known to modulate radial migration. (Shikanai M, Nakajima K, Kawauchi T. 2011. N-cadherin regulates radial glial fiber-dependent migration of cortical locomoting neurons. Commun Integr Biol. 4:326-330.) Interestingly, pharmacological inhibition of extracellular signal-regulated kinases (ERK1/2) also decreases the expression of N-cadherin, implicating an upstream effect of ERK1/2 on N-cadherin and also suggesting a link between Rab23 and ERK1/2. Further biochemical studies show that silencing of Rab23 impedes activation of ERK1/2 via perturbed platelet-derived growth factor-alpha (PDGFR?) signaling. Restoration of the expression of Rab23 or N-cadherin in Rab23-KD neurons could reverse neuron migration defects, indicating that Rab23 modulates migration through N-cadherin. These studies suggest that cortical neuron migration is mediated by a molecular hierarchy downstream of Rab23 via N-cadherin.
Source Title: Cerebral Cortex
URI: http://scholarbank.nus.edu.sg/handle/10635/152202
ISSN: 10473211
DOI: 10.1093/cercor/bhy018
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