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Title: Correlation of Color Fundus Photograph Grading with Risks of Early Age-related Macular Degeneration by using Automated OCT-derived Drusen Measurements
Authors: Cheung C.M.G. 
Shi Y. 
Tham Y.C.
Sabanayagam C. 
Neelam K. 
Wang J.J. 
Mitchell P.
Cheng C.-Y. 
Wong T.Y. 
Cheung C.Y.L. 
Issue Date: 2018
Publisher: Nature Publishing Group
Citation: Cheung C.M.G., Shi Y., Tham Y.C., Sabanayagam C., Neelam K., Wang J.J., Mitchell P., Cheng C.-Y., Wong T.Y., Cheung C.Y.L. (2018). Correlation of Color Fundus Photograph Grading with Risks of Early Age-related Macular Degeneration by using Automated OCT-derived Drusen Measurements. Scientific Reports 8 (1) : 12937. ScholarBank@NUS Repository.
Abstract: We evaluated automated OCT-derived drusen volume measures in a population-based study (n = 4,512) aged ?40 years, and its correlation with conventional color fundus photographs (CFP)-derived early AMD features. Participants had protocol-based assessment to capture medical and ocular history, genotyping for SNPs in CFH, ARMS2, and CETP, CFP-based AMD grading and automated drusen volume based on SD-OCT using built-in software (Cirrus OCT advanced RPE analysis software). Significantly fewer eyes with early AMD features (drusen, hyperpigmentation, soft or reticular drusen) had drusen volume = 0 mm3 (p < 0.001). In eyes with drusen volume > 0 mm3, increasing AMD severity was associated with increase in drusen volume (correlation coefficient 0.17, p < 0.001). However 220 (59.14%) of 372 participants with AMD based on CFP grading had drusen volume = 0 mm3. Factors associated with drusen volume included age (OR 1.42 per 5 years, 95% confidence interval [CI] 2.76, 4.48), systolic blood pressure (OR1.00, 95% CI 1.00, 1.01), ethnic Malay (OR 1.54, 95% CI 1.29, 1.83) and Chinese (OR 1.66, 95% CI 1.37, 2.01) compared to Indian. The ARMS2 rs10490924 T allele was associated with increased drusen volume in subjects with AMD (multivariable adjusted OR1.54, 95% CI 1.08, 2.19). Automated OCT-derived drusen volume is correlated with CFP-based AMD grading in many, but not all subjects. However the agreement is not good. These two modalities provide complementary information and should be incorporated into future studies. © 2018, The Author(s).
Source Title: Scientific Reports
ISSN: 20452322
DOI: 10.1038/s41598-018-31109-x
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