Please use this identifier to cite or link to this item: https://doi.org/10.1038/ncomms4330
Title: Amyloid precursor protein regulates neurogenesis by antagonizing miR-574-5p in the developing cerebral cortex
Authors: Zhang W.
Thevapriya S.
Kim P.J.
Yu W.-P.
Je H.S.
Tan E.K. 
Zeng L. 
Issue Date: 2014
Publisher: Nature Research
Citation: Zhang W., Thevapriya S., Kim P.J., Yu W.-P., Je H.S., Tan E.K., Zeng L. (2014). Amyloid precursor protein regulates neurogenesis by antagonizing miR-574-5p in the developing cerebral cortex. Nature communications 5 : 3330. ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms4330
Abstract: Amyloid precursor protein (APP) is a transmembrane glycoprotein proteolytically processed to release amyloid beta, a pathological hallmark of Alzheimer's disease. APP is expressed throughout the developing and mature brain; however, the primary function of this protein is unknown. We previously demonstrated that APP deficiency enhances neurogenesis, but the mechanisms underlying this process are not known. Here we show that APP regulates the expression of microRNAs in the cortex and in neural progenitors, specifically repressing miR-574-5p. We also show that overexpression of miR-574-5p promotes neurogenesis, but reduces the neural progenitor pool. In contrast, the reduced expression of miR-574-5p inhibits neurogenesis and stimulates proliferation in vitro and in utero. We further demonstrate that the inhibition of miR-574-5p in APP-knockout mice rescues the phenotypes associated with APP deficiency in neurogenesis. Taken together, these results reveal a mechanism in which APP regulates the neurogenesis through miRNA-mediated post-transcriptional regulation.
Source Title: Nature communications
URI: http://scholarbank.nus.edu.sg/handle/10635/149128
ISSN: 2041-1723
DOI: 10.1038/ncomms4330
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
ncomms4330.pdf4.15 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

16
checked on Aug 19, 2019

WEB OF SCIENCETM
Citations

11
checked on Dec 24, 2018

Page view(s)

45
checked on Aug 15, 2019

Download(s)

1
checked on Aug 15, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.