Please use this identifier to cite or link to this item:
Title: Chronic cerebral hypoperfusion enhances Tau hyperphosphorylation and reduces autophagy in Alzheimers disease mice
Authors: Qiu L. 
Ng G.
Tan E.K. 
Liao P. 
Kandiah N. 
Zeng L. 
Issue Date: 2016
Publisher: Nature Publishing Group
Citation: Qiu L., Ng G., Tan E.K., Liao P., Kandiah N., Zeng L. (2016). Chronic cerebral hypoperfusion enhances Tau hyperphosphorylation and reduces autophagy in Alzheimers disease mice. Scientific Reports 6 : 23964. ScholarBank@NUS Repository.
Abstract: Cerebral hypoperfusion and impaired autophagy are two etiological factors that have been identified as being associated with the development of Alzheimers disease (AD). Nevertheless, the exact relationships among these pathological processes remain unknown. To elucidate the impact of cerebral hypoperfusion in AD, we created a unilateral common carotid artery occlusion (UCCAO) model by occluding the left common carotid artery in both young and old 3xTg-AD mice. Two months after occlusion, we found that ligation increases phospho-Tau (p-Tau) at Serine 199/202 in the hippocampus of 3-month-old AD mice, compared to sham-operated AD mice; whereas, there is no change in the wild type (WT) mice after ligation. Moreover, cerebral hypoperfusion led to significant increase of p-Tau in both the hippocampus and cortex of 16-month-old AD mice and WT mice. Notably, we did not detect any change in A? 42 level in either young or old AD and WT mice after ligation. Interestingly, we observed a downregulation of LC3-II in the cortex of aged AD mice and WT mice after ligation. Our results suggest that elevated p-Tau and reduced autophagy are major cellular changes that are associated with hypoperfusion in AD. Therefore, targeting p-Tau and autophagy pathways may ameliorate hypoperfusion-induced brain damage in AD.
Source Title: Scientific Reports
ISSN: 20452322
DOI: 10.1038/srep23964
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
srep23964.pdf931.02 kBAdobe PDF




checked on Jun 18, 2019


checked on Dec 19, 2018

Page view(s)

checked on Jun 13, 2019


checked on Jun 13, 2019

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.