Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.scr.2016.12.014
Title: Derivation of human induced pluripotent stem cell (iPSC) line with LRRK2 gene R1398H variant in Parkinson's disease
Authors: Ma D. 
Tio M. 
Ng S.H.
Li Zeng 
Lim C.Y.Y.
Zhao Y.
Tan E.K. 
Issue Date: 2017
Publisher: Elsevier B.V.
Citation: Ma D., Tio M., Ng S.H., Li Zeng, Lim C.Y.Y., Zhao Y., Tan E.K. (2017). Derivation of human induced pluripotent stem cell (iPSC) line with LRRK2 gene R1398H variant in Parkinson's disease. Stem Cell Research 18 : 48-50. ScholarBank@NUS Repository. https://doi.org/10.1016/j.scr.2016.12.014
Abstract: Peripheral blood mononuclear cells (PBMCs) were collected from a clinically diagnosed 72-year old female Parkinson's disease (PD) patient with R1398H variant in the LRRK2 gene. The PMBCs were reprogrammed with the human OSKM transcription factors using the Sendai-virus reprogramming system. The transgene-free iPSC showed pluripotency confirmed by immunofluorescent staining for pluripotency markers and differentiated into the 3 germ layers in vivo. The iPSC line also showed normal karyotype. This cellular model provides a good platform for studying the mechanism of PD, and also for drug testing and gene therapy studies. © 2016 The Authors
Source Title: Stem Cell Research
URI: http://scholarbank.nus.edu.sg/handle/10635/148965
ISSN: 18735061
DOI: 10.1016/j.scr.2016.12.014
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