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Title: Responses of polycystic ovarian syndrome and related variants to low-dose follicle stimulating hormone
Authors: Yong, E.L. 
Ng, S.C. 
Chan, C. 
Kumar, J. 
Teo, L.S.
Ratnam, S. 
Keywords: Chronic low-dose FSH
Polycystic ovarian syndrome
Polycystic ovarian syndrome-like
Issue Date: Jun-1997
Citation: Yong, E.L., Ng, S.C., Chan, C., Kumar, J., Teo, L.S., Ratnam, S. (1997-06). Responses of polycystic ovarian syndrome and related variants to low-dose follicle stimulating hormone. International Journal of Gynecology and Obstetrics 57 (3) : 305-311. ScholarBank@NUS Repository.
Abstract: Objective: To determine whether patients with classical polycystic ovarian syndrome (PCOS) respond differently to low-dose FSH therapy in comparison with anovulatory patients (PCOS-like) where only some features of PCOS are present. Methods: Two groups of patients were studied. The PCOS group (25 patients, 51 cycles) and the PCOS-like group (38 patients, 57 cycles) were treated with the same protocol of purified FSH, commencing with an initial dosage of 75 IU/day and increasing by 37.5 IU/day after 14 days, where necessary. Estradiol levels and ultrasonographic evidence of follicular development were used for monitoring. Results: PCOS patients required more ampules of FSH, needed more days of gonadotropin stimulation, secreted higher levels of E2 and had increased numbers of intermediate follicles compared to the PCOS-like group. Conclusions: This study demonstrated significant differences between PCOS and other PCOS-like conditions when treated with low-dose FSH. Classification of the subvariants of PCOS may have therapeutic implications.
Source Title: International Journal of Gynecology and Obstetrics
ISSN: 00207292
DOI: 10.1016/S0020-7292(97)00072-6
Appears in Collections:Staff Publications

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