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Title: Splenic lymphoma with villus lymphocytes - An uncommon cause for lymphocytosis
Authors: Kuperan, P.
Teo, C.P.
Chong, S.M. 
Liu, T.C.
Keywords: Chronic lymphocytic leukaemia
Splenic lymphoma with villus lymphocytes
Issue Date: 1997
Citation: Kuperan, P., Teo, C.P., Chong, S.M., Liu, T.C. (1997). Splenic lymphoma with villus lymphocytes - An uncommon cause for lymphocytosis. Singapore Medical Journal 38 (9) : 395-398. ScholarBank@NUS Repository.
Abstract: We describe the clinical and laboratory features of four patients who presented with mild to moderate lymphocytosis but with no peripheral lymphadenopathy. These patients in the past, would have been classified as chronic lymphocytic leukaemia (CLL). However, it is now realised that chronic lymphoproliferative disorders are very heterogeneous and the clinical and laboratory features of our patients would support a diagnosis of splenic lymphoma with villus lymphocytes (SLVL) with characteristic morphological features. SLVL usually runs a benign clinical course but symptoms related to splenomegaly or hypersplenism may be a problem. Splenectomy is considered the treatment of choice in these patients. Two of our patients had splenectomy and the other two patients are on regular follow-up without any specific treatment. It is therefore important to recognise this uncommon condition and also to differentiate it from CLL.
Source Title: Singapore Medical Journal
ISSN: 00375675
Appears in Collections:Staff Publications

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