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Title: Fluoroquinolone Resistance in Clinical Isolates of Streptococcus pneumoniae from Asian Countries: ANSORP Study
Authors: Oh, W.S.
Suh, J.Y.
Song, J.-H.
Ko, K.S.
Jung, S.-I.
Peck, K.R.
Lee, N.Y.
Yang, Y.
ChongthaLeong, A. 
Chiu, C.-H.
Kamarulzaman, A.
Parasakthi, N.
Lalitha, M.K.
Perera, J.
Yee, T.T. 
Kumarasinghe, G.
Carlos, C.C.
Issue Date: Mar-2004
Citation: Oh, W.S., Suh, J.Y., Song, J.-H., Ko, K.S., Jung, S.-I., Peck, K.R., Lee, N.Y., Yang, Y., ChongthaLeong, A., Chiu, C.-H., Kamarulzaman, A., Parasakthi, N., Lalitha, M.K., Perera, J., Yee, T.T., Kumarasinghe, G., Carlos, C.C. (2004-03). Fluoroquinolone Resistance in Clinical Isolates of Streptococcus pneumoniae from Asian Countries: ANSORP Study. Microbial Drug Resistance 10 (1) : 37-42. ScholarBank@NUS Repository.
Abstract: Seventeen clinical isolates of Streptococcus pneumoniae showing reduced susceptibility to ciprofloxacin (MIC ≥ 4 μg/ml) collected from eight different Asian countries were analyzed by antimicrobial susceptibility, serotyping, pulsed-field gel electrophoresis (PFGE), and DNA sequencing of the quinolone resistance-determining regions (QRDRs) in gyrA, gyrB, parC, and parE. All isolates but one showed more than one amino acid alteration in QRDRs of four responsible genes. Ile460 → Val in parE was the most common mutation. Data suggest that Lys137 → Asn in parC may be a primary step in the development of high-level and multiple FQ resistance. An additional mutation of Ser81 → Phe in gyrA resulted in high-level resistance to ciprofloxacin, levofloxacin, and gatifloxacin, whereas Ser79 → Phe in parC may exert an important role in the development of moxifloxacin resistance. Two novel amino acid changes in gyrB, Ala390 → Val and Asn423 → Thr, were found. Data from PFGE suggest an introduction and local spread of multiple resistant Spain23F-1 clone in Hong Kong, but isolates from other Asian countries were not related to this clone.
Source Title: Microbial Drug Resistance
ISSN: 10766294
DOI: 10.1089/107662904323047781
Appears in Collections:Staff Publications

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