Please use this identifier to cite or link to this item:
https://doi.org/10.1089/107662904323047781
DC Field | Value | |
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dc.title | Fluoroquinolone Resistance in Clinical Isolates of Streptococcus pneumoniae from Asian Countries: ANSORP Study | |
dc.contributor.author | Oh, W.S. | |
dc.contributor.author | Suh, J.Y. | |
dc.contributor.author | Song, J.-H. | |
dc.contributor.author | Ko, K.S. | |
dc.contributor.author | Jung, S.-I. | |
dc.contributor.author | Peck, K.R. | |
dc.contributor.author | Lee, N.Y. | |
dc.contributor.author | Yang, Y. | |
dc.contributor.author | ChongthaLeong, A. | |
dc.contributor.author | Chiu, C.-H. | |
dc.contributor.author | Kamarulzaman, A. | |
dc.contributor.author | Parasakthi, N. | |
dc.contributor.author | Lalitha, M.K. | |
dc.contributor.author | Perera, J. | |
dc.contributor.author | Yee, T.T. | |
dc.contributor.author | Kumarasinghe, G. | |
dc.contributor.author | Carlos, C.C. | |
dc.date.accessioned | 2016-12-19T06:49:16Z | |
dc.date.available | 2016-12-19T06:49:16Z | |
dc.date.issued | 2004-03 | |
dc.identifier.citation | Oh, W.S., Suh, J.Y., Song, J.-H., Ko, K.S., Jung, S.-I., Peck, K.R., Lee, N.Y., Yang, Y., ChongthaLeong, A., Chiu, C.-H., Kamarulzaman, A., Parasakthi, N., Lalitha, M.K., Perera, J., Yee, T.T., Kumarasinghe, G., Carlos, C.C. (2004-03). Fluoroquinolone Resistance in Clinical Isolates of Streptococcus pneumoniae from Asian Countries: ANSORP Study. Microbial Drug Resistance 10 (1) : 37-42. ScholarBank@NUS Repository. https://doi.org/10.1089/107662904323047781 | |
dc.identifier.issn | 10766294 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/133301 | |
dc.description.abstract | Seventeen clinical isolates of Streptococcus pneumoniae showing reduced susceptibility to ciprofloxacin (MIC ≥ 4 μg/ml) collected from eight different Asian countries were analyzed by antimicrobial susceptibility, serotyping, pulsed-field gel electrophoresis (PFGE), and DNA sequencing of the quinolone resistance-determining regions (QRDRs) in gyrA, gyrB, parC, and parE. All isolates but one showed more than one amino acid alteration in QRDRs of four responsible genes. Ile460 → Val in parE was the most common mutation. Data suggest that Lys137 → Asn in parC may be a primary step in the development of high-level and multiple FQ resistance. An additional mutation of Ser81 → Phe in gyrA resulted in high-level resistance to ciprofloxacin, levofloxacin, and gatifloxacin, whereas Ser79 → Phe in parC may exert an important role in the development of moxifloxacin resistance. Two novel amino acid changes in gyrB, Ala390 → Val and Asn423 → Thr, were found. Data from PFGE suggest an introduction and local spread of multiple resistant Spain23F-1 clone in Hong Kong, but isolates from other Asian countries were not related to this clone. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1089/107662904323047781 | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | PHARMACOLOGY | |
dc.description.doi | 10.1089/107662904323047781 | |
dc.description.sourcetitle | Microbial Drug Resistance | |
dc.description.volume | 10 | |
dc.description.issue | 1 | |
dc.description.page | 37-42 | |
dc.description.coden | MDREF | |
dc.identifier.isiut | 000221015400005 | |
Appears in Collections: | Staff Publications |
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