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Title: Fluorescent in-situ Hybridization - Some of its Applications in Clinical Cytogenetics
Authors: Gole, L.A. 
Bongso, A. 
Keywords: Applications in clinical cytogenetics
Fluorescent in-situ hybridization
Issue Date: Nov-1997
Citation: Gole, L.A., Bongso, A. (1997-11). Fluorescent in-situ Hybridization - Some of its Applications in Clinical Cytogenetics. Singapore Medical Journal 38 (11) : 497-503. ScholarBank@NUS Repository.
Abstract: Fluorescent in-situ hybridization (FISH) is becoming more and more relevant as an important future tool in prenatal and preimplantation genetic diagnosis and cancer cytogenetics. This review describes the FISH technique as applied to whole chromosome spreads and interphase cells and discusses its applications in clinical cytogenetics. Information is presented on the various types of probes and the subsequent hybridization and detection procedures. The potential use of this novel FISH technique in the diagnosis of numerical and structural chromosomal aberrations in routine karyotyping for prenatal diagnosis, tumour cytogenetics and pre-implantation genetic diagnosis is outlined.
Source Title: Singapore Medical Journal
ISSN: 00375675
Appears in Collections:Staff Publications

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