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https://doi.org/10.1159/000114300
Title: | Positive association between plasma homocysteine level and chronic kidney disease | Authors: | Shankar, A. Wang, J.J. Chua, B. Rochtchina, E. Flood, V. Mitchell, P. |
Keywords: | Blue Mountains Eye Study Chronic kidney disease Hypertension Plasma homocysteine |
Issue Date: | Feb-2008 | Citation: | Shankar, A., Wang, J.J., Chua, B., Rochtchina, E., Flood, V., Mitchell, P. (2008-02). Positive association between plasma homocysteine level and chronic kidney disease. Kidney and Blood Pressure Research 31 (1) : 55-62. ScholarBank@NUS Repository. https://doi.org/10.1159/000114300 | Abstract: | Background: Increasing experimental evidence, including recently developed animal models, supports a role for homocysteine in the development of chronic kidney disease (CKD). However, relatively few clinical/epidemiological studies have examined this hypothesis in humans. We examined the relationship between plasma homocysteine level and CKD in a population-based study of older Australians. Methods: Community-based study (1992-1994) among 2,609 individuals (58.6% women), aged 49-98 years, free of clinical cardiovascular disease in the Blue Mountains region, west of Sydney, Australia. The main outcome-of-interest was CKD (n = 461), defined as estimated glomerular filtration rate of 14 μmol/l) to quartile 1 (≤9 μmol/l) was 10.44 (6.99-15.60), p-trend | Source Title: | Kidney and Blood Pressure Research | URI: | http://scholarbank.nus.edu.sg/handle/10635/132789 | ISSN: | 14204096 | DOI: | 10.1159/000114300 |
Appears in Collections: | Staff Publications |
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