Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/132608
Title: Nerve anastomosis with glue: Comparative histologic study of fibrin and cyanoacrylate glue
Authors: Wieken, K.
Angioi-Duprez, K.
Lim, A. 
Marchal, L.
Merle, M.
Keywords: Cyanocrylate
Fibrin
Glue
Nerve repair
Issue Date: Jan-2003
Citation: Wieken, K., Angioi-Duprez, K., Lim, A., Marchal, L., Merle, M. (2003-01). Nerve anastomosis with glue: Comparative histologic study of fibrin and cyanoacrylate glue. Journal of Reconstructive Microsurgery 19 (1) : 17-20. ScholarBank@NUS Repository.
Abstract: The authors report the results of a comparative experimental nerve study, using a biologic tissue glue (fibrin) and a synthetic glue (2-cyanoacrylate) in a rat model. A tension-free repair is necessary with the use of fibrin glue, or gapping may occur, thus limiting the use of the agent in promoting re-neurotization. In addition, the human origin of fibrin and thrombin allow for the possibility of viral transmission. The aim of the study was to verify if the synthetic glue is a viable alternative, or whether it causes cellular and tissue lesions. Their main finding was that the cyanoacrylate causes a foreign-body inflammatory reaction and retractile fibrosis, often reducing the nerve diameter up to two-thirds. Cyanoacrylate glue is thus not recommended for peripheral nerve repair.
Source Title: Journal of Reconstructive Microsurgery
URI: http://scholarbank.nus.edu.sg/handle/10635/132608
ISSN: 0743684X
Appears in Collections:Staff Publications

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