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|Title:||Nerve anastomosis with glue: Comparative histologic study of fibrin and cyanoacrylate glue||Authors:||Wieken, K.
|Issue Date:||Jan-2003||Citation:||Wieken, K., Angioi-Duprez, K., Lim, A., Marchal, L., Merle, M. (2003-01). Nerve anastomosis with glue: Comparative histologic study of fibrin and cyanoacrylate glue. Journal of Reconstructive Microsurgery 19 (1) : 17-20. ScholarBank@NUS Repository.||Abstract:||The authors report the results of a comparative experimental nerve study, using a biologic tissue glue (fibrin) and a synthetic glue (2-cyanoacrylate) in a rat model. A tension-free repair is necessary with the use of fibrin glue, or gapping may occur, thus limiting the use of the agent in promoting re-neurotization. In addition, the human origin of fibrin and thrombin allow for the possibility of viral transmission. The aim of the study was to verify if the synthetic glue is a viable alternative, or whether it causes cellular and tissue lesions. Their main finding was that the cyanoacrylate causes a foreign-body inflammatory reaction and retractile fibrosis, often reducing the nerve diameter up to two-thirds. Cyanoacrylate glue is thus not recommended for peripheral nerve repair.||Source Title:||Journal of Reconstructive Microsurgery||URI:||http://scholarbank.nus.edu.sg/handle/10635/132608||ISSN:||0743684X|
|Appears in Collections:||Staff Publications|
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